Apr 1, 2020

A bidirectional Mendelian randomization study of glycemic and anthropometric traits and Parkinsons disease

BioRxiv : the Preprint Server for Biology
S. GroverManu Sharma

Abstract

Importance: Impaired glucose and obesity are known characteristics of patients with PD, although it is unclear whether the dysfunction precedes or results from the neurodegeneration. Objective: To assess whether glycemic traits and anthropometric traits can influence the risk of PD in 33,674 cases and 449,056 healthy controls using Mendelian randomization (MR) framework. Design, setting, and participants: We investigated causality with a two-sample bidirectional MR approach in the European population. We used the inverse variance-weighted (IVW), weighted median (WME), and weighted mode (MBE) methods to compute effect estimates with summary statistics from available meta-analyses of genome-wide association studies (GWAS) on glycemic and anthropometric traits that used discovery cohorts. We conducted sensitivity analyses with prioritized genetic instruments that used different study designs including employment of different study cohorts and body mass index (BMI) adjusted exposures, and exclusion of overlapping samples between risk factors and outcome datasets, and potential pleiotropic genetic instruments. Main outcome and measures: PD, glycemic and anthropometric traits. Results: We observed a risky effect of PD on fasting gluc...Continue Reading

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