PMID: 11309440Apr 20, 2001Paper

Testing for colon neoplasia susceptibility variants at the human COX2 locus

Journal of the National Cancer Institute
G L WiesnerS D Markowitz

Abstract

Siblings and other first-degree relatives of patients with "sporadic" (i.e., apparently nonfamilial) colorectal cancer or precursor adenomatous colon polyps have an increased risk of developing colon neoplasia. This observation suggests the presence of inherited genetic determinants for sporadic colon neoplasia. Mice homozygous for a null cyclooxygenase 2 (COX2) (also called PTGS2) allele have a dramatically reduced susceptibility to the development of intestinal adenomas. In humans, use of pharmacologic inhibitors of COX2 enzyme activity are associated with reduced risk of colon neoplasia. This study examined whether the human COX2 locus may be linked to colon neoplasia in humans. We used the affected sibling-pair method to test for linkage of the human COX2 locus to colon neoplasia. We examined 74 concordantly affected sibling pairs from 46 sibships with colon neoplasia. One hundred five siblings from these sibships were diagnosed with either colorectal cancer or colon adenomatous polyps before age 65 years. No linkage between COX2 and colon neoplasia was found by use of a multipoint model-free linkage analysis (estimate of allele sharing was 0.44; standard error = +/-0.04; 95% confidence interval = 0.36 to 0.52). Moreover, e...Continue Reading

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Citations

Oct 18, 2001·Journal of the National Cancer Institute·C M Ulrich, J D Potter
Dec 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J EdwardsJ M S Bartlett
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georgia L WiesnerSanford D Markowitz
May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Farid E Ahmed
Feb 22, 2002·Oncogene·Hui LiSanford Markowitz

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