Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models.

Molecular and Cellular Endocrinology
Stephan CouderqJean-Baptiste Fini

Abstract

Thyroid hormones (THs) play critical roles in profound changes in many vertebrates, notably in mammalian neurodevelopment, although the precise molecular mechanisms of these fundamental biological processes are still being unravelled. Environmental and health concerns prompted the development of chemical safety testing and, in the context of endocrine disruption, identification of thyroid hormone axis disrupting chemicals (THADCs) remains particularly challenging. As various molecules are known to interfere with different levels of TH signalling, screening tests for THADCs may not rely solely on in vitro ligand/receptor binding to TH receptors. Therefore, alternatives to mammalian in vivo assays featuring TH-related endpoints that are more sensitive than circulatory THs and more rapid than thyroid histopathology are needed to fulfil the ambition of higher throughput screening of the myriad of environmental chemicals. After a detailed introduction of the context, we have listed current assays and parameters to assess thyroid disruption following a literature search of recent publications referring to non-mammalian models. Potential THADCs were mostly investigated in zebrafish and the frog Xenopus laevis, an amphibian model exten...Continue Reading

References

Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·F Brucker-Davis
Jun 13, 2002·Environmental Health Perspectives·Kembra L Howdeshell
Jan 28, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Neepa Y ChoksiMichael Shelby
Dec 13, 2005·General and Comparative Endocrinology·Bert De GroefEduard R Kühn
May 9, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Burkhard AltKlaus B Rohr
Feb 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Juan Bernal
Mar 17, 2007·Critical Reviews in Toxicology·R Thomas ZoellerRochelle W Tyl
Mar 17, 2007·Critical Reviews in Toxicology·R Thomas Zoeller, Shirlee W Tan
Apr 24, 2007·Developmental Biology·Donald D Brown, Liquan Cai
Jun 19, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Bruno Hagenbuch
Sep 19, 2007·Environmental Science & Technology·Jean-Baptiste FiniBarbara A Demeneix
Jan 26, 2008·International Journal of Andrology·Kevin M Crofton
Apr 1, 1992·Trends in Endocrinology and Metabolism : TEM·V A Galton
Jul 29, 2008·Molecular and Cellular Endocrinology·Ghislaine Morvan-DuboisLaurent M Sachs
Apr 2, 2009·Environmental Health Perspectives·Julia R Barrett
Jun 2, 2009·Molecular and Cellular Endocrinology·P PorazziL Persani
Sep 22, 2009·Molecular and Cellular Endocrinology·Sigrun Horn, Heike Heuer
Sep 21, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Nisha S SipesThomas B Knudsen
Sep 24, 2011·Molecular and Cellular Endocrinology·Malene BoasKatharina M Main
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Mar 31, 2012·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Jeffrey FisherDavid Mattie
Apr 7, 2012·Journal of Toxicologic Pathology·Kaori Miyata, Keiko Ose
Nov 28, 2012·Aquatic Toxicology·Joseph E TietgeMichael W Hornung
Apr 23, 2013·General and Comparative Endocrinology·Marjolein HeijlenVeerle M Darras
Jun 12, 2013·Frontiers in Endocrinology·Bert De GroefVeerle M Darras
Aug 10, 2013·Disease Models & Mechanisms·Kara G Pratt, Arseny S Khakhalin
Oct 15, 2013·Environmental Toxicology and Chemistry·Li-Qin YuHuai-Dong Zhou
Nov 21, 2013·Thyroid : Official Journal of the American Thyroid Association·Donald F Sellitti, Koichi Suzuki
Nov 28, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Olympia KoulouriMark Gurnell
Apr 3, 2014·The Journal of Clinical Investigation·Steffen MayerlHeike Heuer
May 2, 2014·European Thyroid Journal·Robert OpitzSabine Costagliola
Jun 1, 2014·Molecular Endocrinology·Marco A CampinhoDeborah M Power
Sep 10, 2014·Molecular and Cellular Endocrinology·Tracie R BakerWarren Heideman

❮ Previous
Next ❯

Citations

Jan 15, 2021·Reproductive Toxicology·Andrea Rodríguez-CarrilloMariana F Fernández
May 1, 2021·International Journal of Molecular Sciences·Hung-Jin HuangHui-Wen Chiu
May 30, 2021·Environmental Pollution·ZhiChao DangAude Kienzler
Jul 19, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Josef Köhrle, Caroline Frädrich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hormones : International Journal of Endocrinology and Metabolism
Thomas R Zoeller
European Journal of Endocrinology
Malene BoasKatharina M Main
Critical Reviews in Toxicology
R Thomas Zoeller, Shirlee W Tan
© 2021 Meta ULC. All rights reserved