Testing of an intrathoracic artificial lung in a pig model

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Keith E CookC Mavroudis

Abstract

A low input impedance, intrathoracic artificial lung is being developed for use in acute respiratory failure or as a bridge to transplantation. The device uses microporous, hollow fibers in a 0.74 void fraction, 1.83 m2 surface area bundle. The bundle is placed within a thermoformed polyethylene terephthalate glucose modified housing with a gross volume of 800 cm3. The blood inlet and outlet are 18 mm inner diameter vascular grafts. Between the inlet graft and the device is a 1 inch inner diameter, thin-walled, latex tubing compliance chamber. These devices were implanted in Yorkshire pigs via median sternotomy with an end to side anastomosis to the pulmonary artery and left atrium. The distal pulmonary artery was occluded to divert the right ventricular output to the device. Pigs 1 and 2 were supported fully for 24 hrs and then killed. Pig 3 was supported partially for 20 hrs and died from bleeding complications. The first implant, in a 55 kg male pig, transferred an average of 176 ml/min +/- 42.4 of O2 and 190 ml/min +/- 39.7 of CO2 with an average blood flow rate of 2.71/min +/- 0.46. The normalized average right ventricular output power, Pn, was 0.062 W/(L/min) +/- 0.0082, and the average device resistance, R, was 3.5 mmHg/...Continue Reading

Citations

Nov 11, 2005·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Kazutoshi KotaniNobuyoshi Shimizu
Apr 3, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan W HaftRobert H Bartlett
Dec 1, 2001·The Journal of Thoracic and Cardiovascular Surgery·J W HaftR B Hirschl
Jul 27, 2006·Expert Review of Medical Devices·Brittany A ZwischenbergerJoseph B Zwischenberger
Feb 10, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·F BoschettiL F Mockros
Nov 29, 2002·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Keith E CookLyle F Mockros
Dec 6, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Federica BoschettiLyle F Mockros
Oct 23, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Heide J EashWilliam J Federspiel
Aug 11, 2006·Cardiovascular Engineering·Roy R HaJohn W Clark
Nov 23, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yu-chun LinJoseph L Bull
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carrie E Perlman, Lyle F Mockros
Jun 6, 2008·Journal of Biomechanical Engineering·Jennifer R ZierenbergJames B Grotberg
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Keith E CookLyle F Mockrost
Sep 15, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Carrie E PerlmanLyle F Mockros
Oct 27, 2005·Surgery Today·Kazutoshi KotaniNobuyoshi Shimizu
Dec 13, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·John W McGillicuddyKeith E Cook
Sep 29, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S D LickS I Merz
Aug 3, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J B ZwischenbergerR H Bartlett
Jul 26, 2002·Perfusion·Joseph B Zwischenberger, Scott K Alpard

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