Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial NCCTG N08C1 (Alliance)

Cancer Medicine
Ganesh K BooraAndreas S Beutler

Abstract

Paclitaxel-induced peripheral neuropathy (PIPN) cannot be predicted from clinical parameters and might have a pharmacogenomic basis. Previous studies identified single nucleotide variants (SNV) associated with PIPN. However, only a subset of findings has been confirmed to date in more than one study, suggesting a need for further re-testing and validation in additional clinical cohorts. Candidate PIPN-associated SNVs were identified from the literature. SNVs were retested in 119 patients selected by extreme phenotyping from 269 in NCCTG N08C1 (Alliance) as previously reported. SNV genotyping was performed by a combination of short-read sequencing analysis and Taqman PCR. These 22 candidate PIPN SNVs were genotyped. Two of these, rs7349683 in the EPHA5 and rs3213619 in ABCB1 were found to be significantly associated with PIPN with an Odds ratios OR = 2.07 (P = 0.02) and OR = 0.12 (P = 0.03), respectively. In addition, three SNVs showed a trend toward a risk- or protective effect that was consistent with previous reports. The rs10509681 and rs11572080 in the gene CYP2C8*3 showed risk effect with an OR = 1.49 and rs1056836 in CYP1B1 showed a protective effect with an OR = 0.66. None of the other results supported the previously re...Continue Reading

References

Dec 1, 1991·Statistics in Medicine·D G Altman
Mar 20, 2004·BMJ : British Medical Journal·Marion K CampbellUNKNOWN CONSORT group
Aug 3, 2005·PLoS Medicine·John P A Ioannidis
Dec 15, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Suresh V AmbudkarZuben E Sauna
Sep 5, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tristan M SissungStephan Mielke
Oct 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon MarshRobert Brown
Jan 16, 2009·Basic & Clinical Pharmacology & Toxicology·Henrik GréenCurt Peterson
Mar 10, 2010·The Pharmacogenomics Journal·S LeskeläC Rodríguez-Antona
Apr 28, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sophie E RowbothamAnn K Daly
Jul 16, 2010·Breast Cancer Research and Treatment·Roberta RizzoAlessandra Ferlini
Nov 10, 2010·Nature Reviews. Neurology·Guido Cavaletti, Paola Marmiroli
Feb 18, 2011·European Journal of Clinical Pharmacology·Troels K BergmannCurt Peterson
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziDaniel H Lachance
Aug 19, 2011·Glia·Keith K Murai, Elena B Pasquale
Apr 25, 2012·Breast Cancer Research and Treatment·Daniel L HertzE Claire Dees
Jul 31, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Michael BaldwinDeanna L Kroetz
Jan 1, 2010·Oncology Letters·Anna OfverholmCharlotta Enerbäck
Dec 12, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Inés LlaudóNúria Lloberas
Feb 16, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D L HertzE C Dees
Jun 19, 2013·Journal of Medical Genetics·Luis J Leandro-GarcíaCristina Rodríguez-Antona
Mar 7, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean E AbrahamHelena M Earl
Apr 8, 2014·Breast Cancer Research and Treatment·Daniel L HertzHoward L McLeod
Apr 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn L HershmanCharles L Loprinzi
Aug 29, 2014·Annals of Neurology·Andreas S BeutlerCharles L Loprinzi

❮ Previous
Next ❯

Citations

Jul 1, 2017·Nature Reviews. Neurology·Andreas A ArgyriouGuido Cavaletti
Nov 23, 2017·Frontiers in Pharmacology·Raffaele Di FranciaMassimiliano Berretta
Jul 26, 2018·Biomarkers in Medicine·Patrick L DiazCarlo DeAngelis
Nov 9, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S B ParkM Friedlander
Dec 12, 2019·British Journal of Clinical Pharmacology·Lauren A MarcathDaniel L Hertz
Jul 15, 2017·Current Opinion in Anaesthesiology·Peggy Y Kim, Carrie E Johnson
Apr 11, 2020·Clinical Pharmacology and Therapeutics·Tore B StageDeanna L Kroetz
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Lindsay M MortonM Eileen Dolan
Aug 1, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alexandre ChanMaryam B Lustberg
Jun 18, 2017·Frontiers in Molecular Neuroscience·Hana Starobova, Irina Vetter
May 28, 2019·Frontiers in Genetics·Michela Panarella, Kelly M Burkett
Oct 28, 2019·Journal of the Peripheral Nervous System : JPNS·Stefano TamburinAndreas A Argyriou
May 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuiying HuMaryam B Lustberg
Feb 6, 2020·Journal of the Neurological Sciences·Jennifer G Le-RademacherAndreas S Beutler
Jun 16, 2021·Expert Opinion on Drug Metabolism & Toxicology·Zeina N Al-MahayriBassam R Ali
Nov 1, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S B ParkM Friedlander

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

R
SDS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.