PMID: 6403850Apr 1, 1983Paper

Testing the mutagenicity of malondialdehyde and formaldehyde by the Drosophila mosaic and the sex-linked recessive lethal tests

Mutation Research
J SzabadG Héjja

Abstract

The mutagenicities of malondialdehyde and formaldehyde were tested by screening each for genetic mosaics of Drosophila melanogaster and by the Muller-5 test for sex-linked recessive lethal mutations. For comparison, the effects of X-rays were also assayed by the above technique. Malondialdehyde, a degradation product of polyunsaturated fatty acids, was found to be a weak mutagen by the above criteria; it induced point mutations and chromosome exchanges at low frequency, as proved by the mosaic test, but failed to induce detectable sex-linked lethality. Formaldehyde was more mutagenic than malondialdehyde; beside induction of mosaic spots it induced sex-linked recessive lethal mutations, but only in the larval testes of Drosophila. Formaldehyde also induced disintegration of the clones. Formaldehyde treatment (feeding larvae with formaldehyde-containing food for about 4 days) was 5 times more mutagenic than malondialdehyde treatment and 5 times less effective than irradiation by 1000 R of X-rays. Wing mosaicism offers a more sensitive way to detect mutagenesis as compared with eye mosaicism. It is suggested that aldehyde-induced mosaic spots derive from mitotic recombination and point mutations.

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Citations

Dec 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Jowett
Dec 1, 1992·Mutation Research·E W Vogel
Mar 1, 1988·Mutation Research·C E VacaM Harms-Ringdahl
Mar 1, 1993·Mutation Research·M A JacksonM D Waters
Oct 1, 1995·Mutation Research·J A FerreiroM A Comendador
Apr 1, 1989·Mutation Research·U GrafF E Würgler
Jun 1, 1991·Mutation Research·N K Tripathy, K K Patnaik
Sep 1, 1990·Mutation Research·S ZimmeringE Pimental
Oct 1, 1992·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J SchlatterU Graf
Nov 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N K TripathyA A Kumar
Jun 1, 1984·Toxicology Letters·A D KligermanG L Erexson
Mar 23, 2005·Mutation Research·Maria Cristina MuneratoHeloísa Helena Rodrigues de Andrade
Dec 1, 1984·Environmental Health Perspectives
Dec 17, 2002·Cell Stress & Chaperones·Olga A IsaenkoMartin E Feder
Dec 22, 2004·Environmental and Molecular Mutagenesis·Mar Rojas-MolinaAngeles Alonso-Moraga
Jun 21, 2015·European Journal of Nutrition·Maryam Abimbola MikailMohammad Noor Adros Yahya

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