Testing the "rate of living" model: further evidence that longevity and metabolic rate are not inversely correlated in Drosophila melanogaster

Journal of Applied Physiology
Wayne A Van VoorhiesJ W Curtsinger

Abstract

In a recent study examining the relationship between longevity and metabolism in a large number of recombinant inbred Drosophila melanogaster lines, we found no indication of the inverse relationship between longevity and metabolic rate that one would expect under the classical "rate of living" model. A potential limitation in generalizing from that study is that it was conducted on experimental material derived from a single set of parental strains originally developed over 20 years ago. To determine whether the observations made with those lines are characteristic of the species, we studied metabolic rates and longevities in a second, independently derived set of recombinant inbred lines. We found no correlation in these lines between metabolic rate and longevity, indicating that the ability to both maintain a normal metabolic rate and have extended longevity may apply to D. melanogaster in general. To determine how closely our measurements reflect metabolic rates of flies maintained under conditions of life span assays, we used long-term, flow-through metabolic rate measurements and closed system respirometry to examine the effects of variables such as time of day, feeding state, fly density, mobility of the flies, and nitro...Continue Reading

References

Sep 1, 1976·Mechanisms of Ageing and Development·J MiquelH Atlan
Mar 1, 1991·Journal of Gerontology·S N Austad, K E Fischer
Jan 1, 1988·Experimental Gerontology·R ArkingR Pretzlaff
Aug 1, 1985·Heredity·L S Luckinbill, M J Clare
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Oct 31, 1998·Current Opinion in Genetics & Development·L D Wilsbacher, J S Takahashi
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·W A Van Voorhies, S Ward
Feb 28, 2001·Physiological and Biochemical Zoology : PBZ·J P Hayes
May 29, 2002·Free Radical Biology & Medicine·Anne-Cécile V Bayne, Rajindar S Sohal
Jun 4, 2002·The Journal of Nutrition·John R SpeakmanE Jean Harper
Sep 5, 2002·Free Radical Biology & Medicine·Rajindar S Sohal
Sep 5, 2002·Free Radical Biology & Medicine·Rajindar S SohalWilliam C Orr
Oct 26, 2002·Free Radical Biology & Medicine·Gustavo Barja
Jan 11, 2003·Free Radical Biology & Medicine·Michelle Keaney, David Gems
Feb 13, 2003·Experimental Gerontology·William C Orr, Rajindar S Sohal
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·James H MardenStephen L Helfand
Jul 29, 2003·Aging Cell·Daniel E L Promislow, Tamara S Haselkorn
Sep 2, 2003·Journal of Applied Physiology·Wayne A van VoorhiesJames W Curtsinger
May 4, 2004·Journal of Insect Physiology·Wayne A Van VoorhiesJames W Curtsinger
Sep 1, 1984·Evolution; International Journal of Organic Evolution·Leo S LuckinbillSteven A Buck

❮ Previous
Next ❯

Citations

May 20, 2008·Biogerontology·Alexander M VaisermanPavel E Grigoriev
May 12, 2011·Integrative and Comparative Biology·Steven N Austad
Sep 15, 2009·The Journal of Experimental Biology·Wayne A Van Voorhies
Apr 19, 2005·Genetics·Sergey V NuzhdinJames W Curtsinger
Jan 18, 2008·Physiological and Biochemical Zoology : PBZ·Lobke M VaanholtG Henk Visser
Nov 15, 2011·Free Radical Biology & Medicine·Rajindar S Sohal, William C Orr
Jul 9, 2008·Journal of Insect Physiology·Wayne A Van VoorhiesJoseph B Williams
Jul 19, 2005·Ageing Research Reviews·Michael S GrotewielEric Cook-Wiens
Jul 5, 2005·Mechanisms of Ageing and Development·David C Samuels
May 28, 2014·Biological Reviews of the Cambridge Philosophical Society·Douglas S Glazier
Jan 19, 2011·Journal of Insect Physiology·Dimitri A SkandalisGlenn J Tattersall
Jan 25, 2014·Journal of Insect Physiology·Palle JensenTorsten Nygaard Kristensen
May 26, 2017·Sleep·Bethany A StahlAlex C Keene
Dec 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Venkatesh Nagarajan-RadhaDamian K Dowling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.