Testing the unique amplification event and the worldwide migration hypothesis of insecticide resistance genes with sequence data

Heredity
T GuillemaudMichel Raymond

Abstract

In the mosquito Culex pipiens, over-production of esterases is a common insecticide resistance mechanism. Different alleles at the esterase A and B loci are known to occur in natural populations, as shown by enzyme electrophoresis and RFLP studies on the esterase B locus. Here we analyse the variability of the esterase A locus at the nucleotide level in mosquitoes possessing or lacking over-produced esterase A. A surprisingly high level of nucleotide polymorphism is found in coding and noncoding regions, and the extent of polymorphism detected is higher than that previously described for the most polymorphic loci in Drosophila. We also show that eight strains from different localities (Africa, America, Asia) that possess the over-produced esterase A2 share the same nucleotide sequence at the esterase A locus, strongly supporting the evolutionary scenario of a unique event of amplification of this gene followed by dispersal through migration rather than the occurrence of multiple independent mutational events of the gene.

References

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Citations

Oct 1, 1996·Biochemical Genetics·D BourguetM Arpagaus
Apr 28, 2004·Insect Biochemistry and Molecular Biology·D S Buss, A Callaghan
Sep 16, 2000·Insect Biochemistry and Molecular Biology·J Hemingway
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M RaymondN Pasteur
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M A Hoy
Apr 1, 1997·Medical and Veterinary Entomology·C SeveriniM Raymond
Oct 3, 2001·Journal of Medical Entomology·N PasteurA B Failloux
Apr 17, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Hemlata SrivastavaAparup Das
Nov 30, 2005·Journal of Evolutionary Biology·P LabbeM Raymond
Feb 12, 2005·Insect Biochemistry and Molecular Biology·James A AnsteadIan Denholm
Mar 8, 2014·Insect Biochemistry and Molecular Biology·A IliasA Tsagkarakou
Jul 13, 2006·Insect Biochemistry and Molecular Biology·Francesco NardiFrancesco Frati
May 16, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·D BourguetD A Andow
Dec 21, 2005·Journal of Medical Entomology·Huqi LiuNannan Liu
Apr 1, 1998·Evolution; International Journal of Organic Evolution·Thomas GuillemaudMichel Raymond
Jul 3, 1998·Genetics·T LenormandM Raymond

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