Testing toxicity of multiple intravitreal injections of bevacizumab in rabbit eyes

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Weiqi XuXiaodong Sun

Abstract

To evaluate the potential toxicity of repeated intravitreal injections of bevacizumab in rabbit eyes. Randomized, placebo-controlled experimental animal study. Fourteen chinchilla rabbits; 12 assigned to the experimental group and 2 assigned to the normal control group. Three sequential, biweekly, intravitreal injections of bevacizumab in doses of 2.5 mg/0.1 mL or 5.0 mg/0.2 mL were performed on each rabbit. Evaluations included intraocular pressure (IOP), aqueous flare, B-scan ultrasound, fundus photography, ultrasound biomicroscopy, electroretinography (ERG), and visually evoked potentials (VEPs) performed at baseline and during the follow-up period. The eyes were enucleated at 1 week and 4 weeks after the last intravitreal injection, and underwent light and electron microscopic evaluations, as well as testing for apoptotic activity. After intravitreal injections, no changes were found by regular clinical observation and IOP tests. There was no significant difference in the anterior chamber inflammatory activity evaluated by the laser flare meter. No evidence of retinal toxicity was seen after intravitreal bevacizumab at doses of 2.5 and 5.0 mg by either ERG or flash VEPs. Electron microscopy did show the presence of inflamma...Continue Reading

References

Dec 6, 2000·The Journal of Clinical Investigation·Y KasaharaN F Voelkel
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz KabbinavarEmily Bergsland
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James C Yang
Mar 2, 2006·Retina·Roberta P A ManzanoMuhamet Kivilcim
Jul 4, 2006·American Journal of Ophthalmology·Sophie J BakriRonald J Marler
Aug 2, 2006·Acta Ophthalmologica Scandinavica·Jayter Silva PaulaIngrid U Scott
Sep 28, 2006·Investigative Ophthalmology & Visual Science·Rogério A CostaIngrid U Scott
Oct 13, 2006·Retina·Leonard FeinerMilam A Brantley
Feb 24, 2007·American Journal of Ophthalmology·Christine Y ChenWilson J Heriot
May 1, 2007·Ophthalmology·Sophie J BakriRavinder J Singh
Dec 11, 2007·American Journal of Ophthalmology·Ziad F BashshurBaha' N Noureddin
Jul 19, 2008·American Journal of Ophthalmology·Tim U KrohneCarsten H Meyer
Sep 25, 2008·Cornea·Priyanka P DoctorC Stephen Foster
Oct 24, 2008·Clinical & Experimental Ophthalmology·Jonathan YeohWilliam G Campbell

❮ Previous
Next ❯

Citations

May 16, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Fabio GasparinFrancisco Max Damico
Sep 24, 2014·Antimicrobial Agents and Chemotherapy·Ying-Cheng ShenLi-Chen Wei
Feb 4, 2014·Expert Review of Clinical Pharmacology·Michael W Stewart
Apr 24, 2020·Toxicologic Pathology·Yoshinori YamagiwaHiroshi Satoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
T KubotaT Ishibashi
Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Sanjay SharmaAshley Brissette
Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
Halil Ibrahim AltinsoyS Ümit Sarici
© 2021 Meta ULC. All rights reserved