Testis conserving chemotherapy in germ cell cancer: its potential to increase understanding of the biology and treatment of carcinoma-in-situ

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
R Tim D OliverJ Shamash

Abstract

Prompted by recognition of the potential of chemotherapy to increase the success of testis conserving surgery in patients with germ cell cancer, background and outcome data are reviewed and their contribution to the ongoing debate about how germ cell cancer develops discussed. The review is based on three previous studies of: a) time trends in tumour size in 578 personal series of all stages of testis cancer treated since 1978; b) impact of chemotherapy on actuarial risk of tumours in contralateral testis examined on 1221 patients treated in trials through the Anglian Germ Cell Cancer Consortium; and c) testes conservation attempted using chemotherapy in 78 patients. Since 1978 tumour size has decreased from 4.8 to 3.0 cms while cure has gone from 77 to 97%. There was no overall long term reduction in second cancers beyond 10 years in stage 1 patients after orchidectomy alone compared to stage 1 or metastatic disease patients receiving chemotherapy though the incidence was non significantly lower up to 10 years particularly in those patients receiving etoposide based combination. Testis conservation was initially successful in 28 of 78 (36%). An additional 25 (32%) had no viable cancer in orchidectomy specimen. In the 28 primar...Continue Reading

References

Jan 1, 1990·British Journal of Urology·R T OliverJ Ong
Sep 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GreistR G Rowland
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R T OliverJ Ong
May 7, 1994·Lancet·R S ChagantiS Mathew
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R T OliverW R Pratt
Apr 1, 1993·International Journal of Andrology·K P Dieckmann, V Loy
Feb 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·H HibiM Yamamoto
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N E SkakkebaekJ Müller
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·R S Chaganti, J Houldsworth
Jul 17, 1998·British Journal of Urology·R RaviW F Hendry
Jul 29, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T B ChristensenH von der Maase
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M PetersenN E Skakkebaek
Nov 7, 2001·The Journal of Urology·A HeidenreichUNKNOWN German Testicular Cancer Study Group
May 2, 2002·Anti-cancer Drugs·Hitoshi YoshijiHiroshi Fukui
Jun 18, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anne-Pascale SatieMichel Samson
Sep 18, 2002·European Urology·Kari Dolven JacobsenAnna E Stenwig
Jul 28, 2011·International Journal of Andrology·Ewa Rajpert-De MeytsNiels E Skakkebaek
Mar 1, 1981·International Journal of Andrology·Jørn Müller, Niels E Skakkebaek

❮ Previous
Next ❯

Citations

Jun 21, 2008·Der Urologe. Ausg. A·L Weissbach, C Schaefer
Apr 18, 2009·World Journal of Urology·Eugene K Lee, Jeffrey M Holzbeierlein
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J Wolter Oosterhuis, Leendert H J Looijenga
Oct 9, 2007·Nature Clinical Practice. Urology·Tim Oliver
May 26, 2006·Annual Review of Genomics and Human Genetics·Niels GregersenJane H Christensen
Jul 26, 2005·Lancet·R T D OliverUNKNOWN MRC TE19 collaborators and the EORTC 30982 collaborators
Feb 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R Timothy D OliverSally P Stenning
Oct 17, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sigmund BrabrandGustav Lehne
Mar 8, 2020·Virchows Archiv : an International Journal of Pathology·Dávid SemjénBéla Kajtár

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
O HerekA Avanoğlu
APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Klaus-Peter DieckmannVolker Loy
BJU International
Erik G HavranekOmer Karim
© 2022 Meta ULC. All rights reserved