Testosterone and Benign Prostatic Hyperplasia

Sexual Medicine Reviews
Giulia RastrelliMario Maggi

Abstract

Benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) are frequent in aging. Nonetheless, their pathogenesis is largely unknown. The androgen dependence of the first phases of prostate development have inspired the historical view that higher testosterone (T) may be involved in BPH occurrence; however, recent evidence suggests a different scenario. To review the available knowledge on the pathogenesis of BPH particularly concerning the role of T and the possible connections with metabolic impairments. Relevant records were retrieved by an extensive search in Medline, including the following keywords ("testosterone"[MeSH Terms] OR "testosterone"[All Fields]) AND ("prostatic hyperplasia"[MeSH Terms] OR ("prostatic"[All Fields] AND "hyperplasia"[All Fields]) OR "prostatic hyperplasia"[All Fields] OR ("benign"[All Fields] AND "prostatic"[All Fields] AND "hyperplasia"[All Fields]) OR "benign prostatic hyperplasia"[All Fields]). There were no limitations in terms of publication date or study design. Preclinical and clinical studies have been reported, with special emphasis on our contribution and interpretation. Inflammation is a key aspect of BPH development. Along with infectious agents, prostate inflammation c...Continue Reading

Citations

Aug 30, 2019·Expert Review of Endocrinology & Metabolism·Giulia RastrelliGiovanni Corona
May 21, 2020·Journal of Aging and Physical Activity·ZhiWei LiuXiangYun Liu
Sep 28, 2020·Pakistan Journal of Biological Sciences : PJBS·Ali Akbar KaramiSeyyed Mehdi Mirhashemi
Jul 31, 2020·Physiological Reviews·Arianna GiacominiMarco Presta
Mar 12, 2021·Frontiers in Endocrinology·Rossella CannarellaAldo E Calogero
Jan 29, 2021·International Neurourology Journal·Min Ho LeeSung Chul Kam
Jun 15, 2021·The Prostate·Nayara Fernanda da Costa CastroPatrícia Simone Leite Vilamaior
Jun 30, 2021·European Urology·Andrea SaloniaUNKNOWN EAU Working Group on Male Sexual and Reproductive Health
Jul 28, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Giuseppe BroggiGiorgio Ivan Russo
Jul 27, 2021·Current Opinion in Pharmacology·Antonio J León-GonzálezRaúl M Luque

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