Sep 1, 1989

Testosterone and its binding in hyperthyroid women before and under antithyroid drug therapy

Acta Endocrinologica
S LoricJ Giboudeau

Abstract

The serum concentrations of the different forms of circulating testosterone, total testosterone, free testosterone and non-sex-hormone binding globulin bound testosterone (albumin bound + free fractions) which is considered as the bioavailable hormone, were measured in 15 hyperthyroid women before and after anti-thyroid drug therapy and in 15 age-matched healthy women. Sex-hormone binding globulin and albumin were quantified. Total testosterone was significantly higher in hyperthyroid women before treatment, whereas free testosterone and non sex-hormone binding globulin bound testosterone were significantly decreased. After recovery, all the parameters returned to the normal range. In hyperthyroid patients, the variations in the different fractions of testosterone can be related to the rise of sex-hormone binding globulin. These variations could be explained by the displacement of the equilibrium defined by the binding equation.

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Mentioned in this Paper

Androgen Receptor
Sex Hormone-Binding Globulin
Testosterone Measurement
Goitrogens
Corticosteroid-Binding Globulin Deficiency
Free testosterone
ALB
Antithyroid Agents
Receptors, Steroid
Neo Tomizol

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