PMID: 40226Jul 1, 1979

Testosterone and its precursors and metabolites enhance guanylate cyclase activity

Proceedings of the National Academy of Sciences of the United States of America
D L Vesely

Abstract

Both testosterone and cyclic GMP stimulate DNA synthesis. Because cyclic GMP and testosterone seem to have similar actions, the objective of this investigation was to determine if testosterone and its precursors might have part of their mechanism of action through stimulation of guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC 4.6.1.2], the enzyme that catalyzes the formation of cyclic GMP from GTP. The precursors--namely, progesterone, pregnenolone, 17 alpha-progesterone, 17 alpha-hydroxypregnenolone, androstenedione, and dehydroepiandrosterone--caused a 2- to 3 1/2-fold enhancement of guanylate cyclase activity in rat liver, kidney, skeletal muscle, and ventral prostate at a concentration of 1 microM. These precursors are generated from cholesterol, which had no effect itself on guanylate cyclase activity. Testosterone, 19-nortestosterone, 17-methyltestosterone, and 5 alpha-dihydrotestosterone enhanced guanylate cyclase activity 2- to 5-fold in the same tissues at 1 microM. Etiocholanolone, androsterone, and epiandrosterone, metabolites of testosterone metabolism, enhanced guanylate cyclase activity 1 1/2- to 2-fold at this same concentration. Dose-response relationships revealed that testosterone and its precursors...Continue Reading

References

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Citations

Nov 1, 1976·Journal of Molecular and Cellular Cardiology·D L VeselyG S Levey
Aug 22, 1977·Biochemical and Biophysical Research Communications·D L VeselyG S Levey
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A J ClaflinG S Levey
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·H Kimura, F Murad
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Related Concepts

Metabolic Process, Cellular
Testosterone Measurement
Pregnenolone
Cyclic GMP Measurement (Lab Test)
Androstenedione Measurement
Epiandrosterone Assay
Androsterone Assay
Progesterone
Lyase
Etiocholanalone Measurement

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