Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats

Hormones and Behavior
Tertia D Purves-TysonCynthia Shannon Weickert

Abstract

Although sex steroids are known to modulate brain dopamine, it is still unclear how testosterone modifies locomotor behaviour controlled, at least in part, by striatal dopamine in adolescent males. Our previous work suggests that increasing testosterone during adolescence may bias midbrain neurons to synthesise more dopamine. We hypothesised that baseline and amphetamine-induced locomotion would differ in adult males depending on testosterone exposure during adolescence. We hypothesised that concomitant stimulation of estrogen receptor signaling, through a selective estrogen receptor modulator (SERM), raloxifene, can counter testosterone effects on locomotion. Male Sprague-Dawley rats at postnatal day 45 were gonadectomised (G) or sham-operated (S) prior to the typical adolescent testosterone increase. Gonadectomised rats were either given testosterone replacement (T) or blank implants (B) for six weeks and sham-operated (i.e. intact or endogenous testosterone group) were given blank implants. Subgroups of sham-operated, gonadectomised and gonadectomised/testosterone-replaced rats were treated with raloxifene (R, 5mg/kg) or vehicle (V), daily for the final four weeks. There were six groups (SBV, GBV, GTV, SBR, GBR, GTR). Saline...Continue Reading

References

Aug 1, 1988·The American Journal of Psychiatry·K A ChristieB Z Locke
Jan 1, 1974·Journal of Psychiatric Research·A Randrup, I Munkvad
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·W W BeattyK L Traylor
Sep 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M H TeicherR J Baldessarini
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·L S SeidenG A Ricaurte
Nov 7, 1998·Brain Research. Developmental Brain Research·C A BolanosD Jackson
Oct 19, 1999·Synapse·C H LammersM M Mouradian
Jan 3, 2003·Archives of Women's Mental Health·J KulkarniH Burger
Oct 2, 2003·Brain Research. Developmental Brain Research·Sylvia E PérezElliott J Mufson
Apr 15, 2004·European Journal of Endocrinology·Erik J J DuschekCoen Netelenbos
Aug 18, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Brigitte UebelhartRené Rizzoli
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marissa I BoulwarePaul G Mermelstein
Jun 16, 2005·Progress in Neurobiology·David SulzerAurelio Galli
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ali SalahpourMarc G Caron
Apr 22, 2008·Human Molecular Genetics·Cynthia Shannon WeickertJoel E Kleinman
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary F Kritzer, Lela M Creutz
Sep 27, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M A de Souza SilvaJ P Huston
Apr 14, 2009·Hormones and Behavior·A Brent RichardsCynthia Shannon Weickert
Feb 11, 2010·The Journal of Steroid Biochemistry and Molecular Biology·K M McNamaraD J Handelsman
Jun 19, 2010·CNS Neuroscience & Therapeutics·Maria Gabriela SánchezThérèse Di Paolo
Jun 19, 2010·CNS Neuroscience & Therapeutics·Giuseppe Di GiovanniVincenzo Di Matteo
May 24, 2011·Reviews in Endocrine & Metabolic Disorders·Julie A Markham
Oct 5, 2012·Biology of Reproduction·Deena M WalkerAndrea C Gore
May 6, 2014·Trends in Pharmacological Sciences·Marco Leyton, Paul Vezina

❮ Previous
Next ❯

Citations

May 10, 2016·Journal of Experimental Neuroscience·Olakunle J OnaolapoTaofeeq Omoleke
Jan 19, 2018·Scientific Reports·Ferran JardíDirk Vanderschueren
May 11, 2018·The Journal of Endocrinology·Ferran JardíFrank Claessens
Sep 25, 2017·Journal of Neuroendocrinology·S J OwensC Shannon Weickert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.