PMID: 6681786Jan 1, 1983

Testosterone-binding protein in a seasonally breeding amphibian

General and Comparative Endocrinology
F L MooreJ C Wingfield


The concentration of testosterone and dihydrotestosterone (DHT) in the plasma of Taricha granulosa rises markedly during the season when androgen-dependent epigamic structures and behaviors recrudesce. During this season (June-October), the physiological characteristics of the testosterone-binding globulin (TeBG) remain unchanged. Competitive binding studies indicate that TeBG binds fairly specifically to testosterone and DHT. The dissociation constant (5 X 10(-8) M) and binding capacities (ranging from 6 to 12 ng androgen bound/ml plasma) were determined using the charcoal adsorption procedures. Because the binding capacity of TeBG remains unchanged when the concentrations of androgens increase, the proportion of testosterone and DHT bound to TeBG is drastically lower during the breeding season, compared to the nonbreeding season. Furthermore, bilateral castration of male newts apparently reduces the binding capacity of TeBG, but Silastic implants of androgen fail to restore the binding capacity.


Oct 1, 1975·Steroids·G C Chamness, W L McGuire
Jul 1, 1979·The Journal of Clinical Investigation·W M Pardridge, L J Mietus
Aug 1, 1979·General and Comparative Endocrinology·C SerniaI R McDonald
Dec 1, 1977·Hormones and Behavior·F L Moore, C H Muller
Nov 3, 1972·Nature·C W Burke, D C Anderson
May 1, 1968·Steroids·A Vermeulen, L Verdonck
Dec 1, 1973·Endocrinology·F Gauthier-WrightP Mauvais-Jarvis
Nov 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·S G Korenman, B R Rao
Apr 1, 1968·Canadian Journal of Biochemistry·B E Murphy
Jul 1, 1967·The Journal of Clinical Endocrinology and Metabolism·W H PearlmanM Murphy
Oct 1, 1980·General and Comparative Endocrinology·A C Salhanick, I P Callard
Jan 1, 1981·Annual Review of Physiology·C W BardinR Becker
Jan 1, 1981·Endocrine Reviews·W M Pardridge
Mar 1, 1981·General and Comparative Endocrinology·F L Moore
Jul 1, 1980·General and Comparative Endocrinology·J M Burns, F L Rose
Nov 1, 1980·General and Comparative Endocrinology·J L Specker, F L Moore


Sep 1, 1986·Journal of Steroid Biochemistry·G Jolivet-Jaudet, J Leloup-Hâtey
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·T A Santa-ColomaE H Charreau
Aug 1, 1994·Molecular Reproduction and Development·S FernandezD C Miceli
Sep 1, 1989·General and Comparative Endocrinology·M S Yu, S M Ho
Sep 1, 1988·General and Comparative Endocrinology·D RileyI P Callard
Nov 1, 1985·General and Comparative Endocrinology·T A Santa-ColomaE H Charreau
Apr 1, 1989·The Journal of Experimental Zoology·S Singh, G Callard

Related Concepts

Androgen Effect
Seasonal Variation
Sex Hormone-Binding Globulin

Related Feeds

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.