Testosterone deprivation has neither additive nor synergistic effects with obesity on the cognitive impairment in orchiectomized and/or obese male rats

Metabolism: Clinical and Experimental
Hiranya PintanaSiriporn C Chattipakorn

Abstract

Previous studies demonstrated a correlation between cognitive decline and either testosterone deprivation or obesity. However, the effect of obesity combined with testosterone deprivation on cognitive function has not been investigated. This study investigated the effects of obesity on brain insulin sensitivity, brain mitochondrial function, hippocampal synaptic plasticity and cognitive function in testosterone-deprived male rats. Male Wistar rats were divided into sham-operated (control) and bilateral orchiectomized (ORX) groups. Rats in each group were further divided into two subgroups to receive either a normal diet (ND) or a high fat diet (HFD) for 4, 8 or 12weeks. Blood samples were collected to determine metabolic parameters. Cognitive function was tested using the Morris Water Maze Test. At the end of the study, brains were removed to investigate brain insulin sensitivity, brain mitochondrial function and hippocampal synaptic plasticity. Both control-obese and ORX-obese rats developed peripheral insulin resistance at week eight, and brain insulin resistance as well as brain mitochondrial dysfunction at week 12. However, the ORX-obese rats developed cognitive impairment and decreased hippocampal synaptic plasticity begin...Continue Reading

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Oct 29, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Hiranya PintanaSiriporn Chattipakorn

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Citations

Mar 24, 2016·The Journal of Endocrinology·Wanpitak PongkanNipon Chattipakorn
Jan 29, 2019·The Journal of Endocrinology·Jirapas SripetchwandeeSiriporn C Chattipakorn
Sep 21, 2018·Frontiers in Endocrinology·Jirapas SripetchwandeeSiriporn C Chattipakorn

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