PMID: 10514558Oct 9, 1999Paper

Testosterone effect on growth and growth mediators of the GH-IGF-I axis in the liver and epiphyseal growth plate of juvenile rats

Journal of Molecular Endocrinology
A ZungZ Zadik

Abstract

Several studies have suggested that testosterone may have a direct, GH-independent effect on growth. In order to assess possible mechanism(s) whereby testosterone exerts its growth-promoting effect, we evaluated its effect on growth mediators of the GH-IGF-I axis, in both the liver and the epiphyseal growth plate (EGP). Testosterone was administered to peripubertal rats and the responses of mRNA of GH receptor, IGF-I, IGF-I receptor and IGF-binding proteins-1 and -3 (IGFBP-1 and IGFBP-3) as well as circulating IGF-I were evaluated in two time-related models: over 12 h after a single injection (short-term study) and 10 days after continuous administration (long-term study). Rats in the short-term study were castrated and were killed 1, 4, 6 and 12 h post injection. Rats in the long-term study were divided into two groups: castrated vs castrated and hypophysectomized, in order to assess the effect of testosterone in the presence and absence of GH. mRNA levels were determined by RNase protection assay, and serum IGF-I by RIA. Testosterone enhanced weight gain in the rats treated for 10 days, a change that was similar in the presence or absence of GH. This effect was relatively small, however, by comparison with the total weight ga...Continue Reading

Citations

Jul 16, 2008·Reviews in Endocrine & Metabolic Disorders·Vita BirznieceKen K Y Ho
Jul 23, 2013·Animal : an International Journal of Animal Bioscience·D DineshkumarS B N Rao
Jun 23, 2012·Journal of Inflammation·Lori D WilsonChristina D Schwindt
Mar 26, 2014·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Tao HuangXinnong Cheng
Nov 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Rosario PivonelloAnnamaria Colao
Jul 6, 2006·Endocrine Journal·M Orhun CamurdanPeyami Cinaz
Dec 13, 2003·Endocrine Reviews·B C J van der EerdenJ M Wit
Aug 17, 2002·Journal of Applied Physiology·Stasa D TadicPatricia K Eagon
Nov 21, 2019·Clinical Endocrinology·Marianna MinnettiMartin O Savage
Mar 10, 2020·Journal of Human Kinetics·Rafał MikołajczykAleksandra Żebrowska
Sep 1, 2005·The Journal of Bone and Joint Surgery. British Volume·T IrieS Kokubun

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