Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress

Hormones and Behavior
Steven R WainwrightLiisa A M Galea

Abstract

Hypogonadal men are more likely to develop depression, while testosterone supplementation shows antidepressant-like effects in hypogonadal men and facilitates antidepressant efficacy. Depression is associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and testosterone exerts suppressive effects on the HPA axis. The hippocampus also plays a role in the feedback regulation of the HPA axis, and depressed patients show reduced hippocampal neuroplasticity. We assessed the antidepressant-like effects of testosterone with, or without, imipramine on behavioral and neural endophenotypes of depression in a chronic unpredictable stress (CUS) model of depression. A 21-day CUS protocol was used on gonadectomized male Sprague-Dawley rats treated with vehicle, 1mg of testosterone propionate, 10mg/kg of imipramine, or testosterone and imipramine in tandem. Testosterone treatment reduced novelty-induced hypophagia following CUS exposure, but not under non-stress conditions, representing state-dependent effects. Further, testosterone increased the latency to immobility in the forced swim test (FST), reduced basal corticosterone, and reduced adrenal mass in CUS-exposed rats. Testosterone also facilitated the effects of imipramin...Continue Reading

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Citations

Mar 19, 2016·Frontiers in Neuroendocrinology·Rand MahmoudLiisa A M Galea
Apr 29, 2018·Molecular Neurobiology·Birgit LudwigYogesh Dwivedi
Feb 8, 2020·Biomolecules·Mark D Spritzer, Ethan A Roy
Jul 14, 2020·Andrology·Michael Zitzmann
Oct 17, 2017·Frontiers in Psychology·Andreas WaltherUlrike Ehlert
Feb 13, 2020·The Libyan Journal of Medicine·Ahmet BerkEbru Kuyumcu Savan
Apr 21, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ya-Nan ZhaoLin Pei
Aug 13, 2020·Biomolecules·Claudia Jorgensen, Zuoxin Wang
May 25, 2021·Journal of Cachexia, Sarcopenia and Muscle·Kouji IzumiAtsushi Mizokami

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