Testosterone improves muscle fiber asset and exercise performance in a metabolic syndrome model

The Journal of Endocrinology
Erica SarchielliMario Maggi

Abstract

Lifestyle modifications, including physical exercise (PhyEx), are well-known treatments for metabolic syndrome (MetS), a cluster of metabolic and cardiovascular risk factors often associated to hypogonadism. Given the trophic role of testosterone on skeletal muscle (SkM), this study was aimed at evaluating the effects of testosterone treatment on SkM metabolism and exercise performance in male rabbits with high-fat diet (HFD)-induced MetS. HFD rabbits, treated or not with testosterone (30 mg/kg/week) for 12 weeks, were compared to regular diet animals (RD). A subset of each group was exercise-trained for 12 weeks. HFD increased type-II (fast, glycolytic) and decreased type-I (slow, oxidative) muscle fibers compared to RD as evaluated by RT-PCR and histochemistry. Testosterone reverted these effects, also inducing the expression of mitochondrial respiration enzymes and normalizing HFD-induced mitochondrial cristae reduction. Moreover, testosterone significantly increased the expression of myogenic/differentiation markers and genes related to glucidic/lipid metabolism. At the end of the PhyEx protocol, when compared to RD, HFD rabbits showed a significant reduction of running distance and running time, while testosterone countera...Continue Reading

Citations

Aug 20, 2020·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Feb 10, 2021·International Journal of Molecular Sciences·Erica SarchielliMario Maggi
Jun 5, 2021·Expert Review of Clinical Pharmacology·Giovanni CoronaMario Maggi
Jun 26, 2021·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Aug 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lin YinGuanhua Du

❮ Previous
Next ❯

Related Concepts

© 2021 Meta ULC. All rights reserved