Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells

FEBS Letters
W P BentenF Wunderlich

Abstract

Using the Fura-2 method we investigated a possible direct action of testosterone on cytosolic free calcium of splenic T cells isolated from female C57BL/10 mice. Testosterone at physiological concentrations of 1-10 nM induces an increase in [Ca2+]i within seconds, which is due to Ca2+ influx and not to Ca2+ release from intracellular stores. In contrast, estradiol induces both Ca2+ influx and Ca2+ release. The testosterone-induced Ca2+ influx is mediated by Ni2+-blockable channels and is not inhibited by cyproterone, a blocker of the classical androgen receptor. Ca2+ influx can also be induced by testosterone conjugated to BSA which is impermeable to the plasma membrane. These data indicate a novel mode of direct action of testosterone on T cells which is not mediated through the classical androgen receptor response, but through unconventional plasma membrane receptors.

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Citations

Apr 19, 2002·Steroids·Frank WunderlichHorst Mossmann
Sep 18, 2002·Steroids·W Peter M BentenFrank Wunderlich
May 22, 2002·Cellular Signalling·Yolanda RománLuis M Botana
Apr 18, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Francis SunnyOommen V Oommen
Mar 5, 1999·Biochimica Et Biophysica Acta·L ZylińskaL Lachowicz
Dec 27, 2006·Prostate Cancer and Prostatic Diseases·K VandykeJ M Blair
Jun 1, 1999·Nutrition Research Reviews·J J AndersonS C Garne
Sep 10, 2010·Cold Spring Harbor Perspectives in Biology·Michael W Harr, Clark W Distelhorst
Dec 25, 2004·Infection and Immunity·Jürgen KrückenFrank Wunderlich
Mar 28, 2008·BMC Physiology·Jonathan TootDaniel Ely
Mar 3, 2010·European Journal of Endocrinology·Alexandra WendlerMartin Wehling
Sep 16, 2006·Immunological Reviews·Monika Fijak, Andreas Meinhardt
Jun 12, 2013·Expert Opinion on Therapeutic Targets·Florian LangChristos Stournaras
Nov 7, 2007·Frontiers in Neuroendocrinology·Guido Michels, Uta C Hoppe
Jun 27, 2002·Science's STKE : Signal Transduction Knowledge Environment·Andrew C B CatoSigrun Mink
Nov 13, 2007·Trends in Endocrinology and Metabolism : TEM·Faisal Rahman, Helen C Christian
Mar 14, 1998·FEBS Letters·W P BentenF Wunderlich
Jan 7, 2004·Nature Reviews. Drug Discovery·Anthony W NormanDerek P G Norman
Oct 6, 2007·Endocrinology·Denise R Goldman-JohnsonJohn R Morrison
Dec 7, 2014·The Journal of Biological Chemistry·Swapna AsuthkarEleonora Zakharian
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maeilena KampaElias Castanas
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabrielle L GoldbergAnn P Chidgey
Sep 28, 2002·Molecular Endocrinology·Cynthia A Heinlein, Chawnshang Chang
Oct 18, 2014·Endocrinology·Laura E Pascal, Zhou Wang

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