Testosterone level and the effect of levodopa and agonists in early Parkinson disease: results from the INSPECT cohort

Journal of Clinical Movement Disorders
Michael S OkunHubert H Fernandez

Abstract

To determine if testosterone levels are influenced by dopaminergic therapy in Parkinson disease (PD) patients. Testosterone level has been reported to be low in patients with PD and other neurodegenerative diseases. In this study, we sought to determine whether dopaminergic therapy (i.e. levodopa and dopamine agonist) influenced testosterone levels. We used a cohort of consecutive male patients from the INSPECT trial--a multi-center, prospective, study that primarily investigated the effects of short-term treatment with pramipexole or levodopa on [(123)I] B-CIT SPECT imaging in early PD. Testosterone levels were drawn on consenting male subjects with early PD who enrolled in the INSPECT trial at three study visits (baseline, 12 weeks post-treatment, and 8-12 weeks post-washout). Subjects were randomized to: no treatment, pramipexole (up to 3 mg) or levodopa (up to 600 mg). Testosterone levels were obtained twice (prior to 10 AM) and averaged for each of three study visits. Thirty two male patients participated in this sub-study and there were no significant differences in disease characteristics in the 3 groups at baseline. Twenty-nine patients completed the follow-up visits and were suitable for analysis. There were statistica...Continue Reading

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Citations

Jan 12, 2021·Sexual Medicine·Claudia Marques Santa Rosa MalcherMarco de Tubino Scanavino
Jan 16, 2021·European Journal of Pharmacology·Bhupesh VaidyaShyam Sunder Sharma
Jun 6, 2021·Parkinsonism & Related Disorders·Chi-Ying Roy LinWissam Deeb

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