Abstract
A constant dose-dependent side-effect in cyclosporin A (CSA)-treated patients is the appearance of hypertrichosis; this occurs in both sexes and suggests an androgenizing activity. To determine the influence of CSA on peripheral androgen metabolism, we evaluated in rheumatoid arthritis (RA) patients treated with low-dose CSA (3.5 mg/kg/day), during a period of 12 months, plasma levels of testosterone (Tes) and of 5alpha-androstane-3alpha, 17beta-diol glucuronide (Adiol-G), an important peripheral Tes metabolite. Clinical and laboratory parameters of RA were also monitored. Furthermore, the metabolism of physiological concentrations of Tes (1 x 10(-8) M) was evaluated in primary cultures of RA synovial macrophages (M phi) in the presence of CSA concentrations close to the pharmacological immunosuppressive doses (100-500 ng/ml). At the final time of observation (12 months), a significant increase in the mean plasma Adiol-G level was observed in patients of both sexes. The increase was evident after 1 month of treatment in male patients (P < 0.01) and after 3 months in female patients (P < 0.05). Almost all the patients experienced the side-effect of a low-degree hypertrichosis after a mean period of 1-2 months. No significant cor...Continue Reading
Citations
Jul 10, 2003·Autoimmunity Reviews·Maurizio CutoloAlberto Sulli
Dec 1, 2005·Reumatología clinica·L J Jara-QuezadaM A Saavedra-Salinas
Jul 23, 1999·Annals of the New York Academy of Sciences·A SulliM Cutolo
May 1, 1997·Annals of the Rheumatic Diseases·M Cutolo
Jun 2, 2007·Biological & Pharmaceutical Bulletin·Yuka ItohKikuo Onozaki
May 26, 2012·International Journal of Trichology·Vinitha Varghese PanickerAd Dhamramaratnam
Oct 11, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Grunewald, U Paasch
Jul 21, 2006·Annals of the New York Academy of Sciences·Martin SchmidtRainer H Straub
Nov 21, 2000·Rheumatic Diseases Clinics of North America·A T Masi
Nov 21, 2000·Rheumatic Diseases Clinics of North America·M Cutolo, R L Wilder
Oct 27, 1999·Rheumatology·G FilaciF Puppo
Nov 5, 2002·Lupus·M Cutolo
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Maurizio CutoloJohannes W J Bijlsma
Jul 23, 1999·Annals of the New York Academy of Sciences·L CastagnettaG Carruba
Mar 27, 2001·Arthritis and Rheumatism·R H Straub, M Cutolo