PMID: 9159535Apr 1, 1997Paper

Testosterone metabolism and cyclosporin A treatment in rheumatoid arthritis

British Journal of Rheumatology
M CutoloL Castagnetta

Abstract

A constant dose-dependent side-effect in cyclosporin A (CSA)-treated patients is the appearance of hypertrichosis; this occurs in both sexes and suggests an androgenizing activity. To determine the influence of CSA on peripheral androgen metabolism, we evaluated in rheumatoid arthritis (RA) patients treated with low-dose CSA (3.5 mg/kg/day), during a period of 12 months, plasma levels of testosterone (Tes) and of 5alpha-androstane-3alpha, 17beta-diol glucuronide (Adiol-G), an important peripheral Tes metabolite. Clinical and laboratory parameters of RA were also monitored. Furthermore, the metabolism of physiological concentrations of Tes (1 x 10(-8) M) was evaluated in primary cultures of RA synovial macrophages (M phi) in the presence of CSA concentrations close to the pharmacological immunosuppressive doses (100-500 ng/ml). At the final time of observation (12 months), a significant increase in the mean plasma Adiol-G level was observed in patients of both sexes. The increase was evident after 1 month of treatment in male patients (P < 0.01) and after 3 months in female patients (P < 0.05). Almost all the patients experienced the side-effect of a low-degree hypertrichosis after a mean period of 1-2 months. No significant cor...Continue Reading

Citations

Jul 10, 2003·Autoimmunity Reviews·Maurizio CutoloAlberto Sulli
Dec 1, 2005·Reumatología clinica·L J Jara-QuezadaM A Saavedra-Salinas
Jul 23, 1999·Annals of the New York Academy of Sciences·A SulliM Cutolo
May 1, 1997·Annals of the Rheumatic Diseases·M Cutolo
May 26, 2012·International Journal of Trichology·Vinitha Varghese PanickerAd Dhamramaratnam
Oct 11, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·S Grunewald, U Paasch
Jul 21, 2006·Annals of the New York Academy of Sciences·Martin SchmidtRainer H Straub
Nov 21, 2000·Rheumatic Diseases Clinics of North America·A T Masi
Nov 21, 2000·Rheumatic Diseases Clinics of North America·M Cutolo, R L Wilder
Oct 31, 2007·Nature Clinical Practice. Rheumatology·Maurizio CutoloJohannes W J Bijlsma
Jul 23, 1999·Annals of the New York Academy of Sciences·L CastagnettaG Carruba

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