PMID: 8979209Dec 1, 1996Paper

Testosterone-producing benign cystic teratoma with virilism. A case report

The Journal of Reproductive Medicine
M W TomlinsonV Alaverdian

Abstract

Mature cystic teratomas are common tumors in reproductive-age women. Biologic activity in a small percentage of these neoplasms is well recognized. Thyroid hormone is the most commonly secreted substance. A 25-year-old woman presented with a large abdominal mass and virilism. Preoperative evaluation revealed elevated creatinine and testosterone levels and anemia. Computed tomography (CT) showed fat-fluid levels and multiple calcifications within the mass and obstruction of the right kidney. At surgery a 30-cm left ovarian mass was removed. Left ovarian vein testosterone levels were markedly elevated. Pathology reported a mature cystic teratoma. Postoperatively the testosterone levels returned to normal. In rare instances androgen production and virilization may occur with mature cystic teratoma.

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