PMID: 9435632Jan 22, 1998Paper

Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males

The American Journal of Physiology
D E RemmersI H Chaudry

Abstract

Although studies have shown that testosterone receptor blockade with flutamide after hemorrhage restores the depressed immune function, it remains unknown whether administration of flutamide following trauma and hemorrhage and resuscitation has any salutary effects on the depressed cardiovascular and hepatocellular functions. To study this, male rats underwent a laparotomy (representing trauma) and were then bled and maintained at a mean arterial pressure (MAP) of 40 mmHg until the animals could not maintain this pressure. Ringer lactate was given to maintain a MAP of 40 mmHg until 40% of the maximal shed blood volume was returned in the form of Ringer lactate. The rats were then resuscitated with four times the shed blood volume in the form of Ringer lactate over 60 min. Flutamide (25 mg/kg) or an equal volume of the vehicle propanediol was injected subcutaneously 15 min before the end of resuscitation. Various in vivo heart performance parameters (e.g., maximal rate of the pressure increase or decrease), cardiac output, and hepatocellular function (i.e., the maximum velocity and the overall efficiency of indocyanine green clearance) were determined at 20 h after resuscitation. Additionally, hepatic microvascular blood flow (H...Continue Reading

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Citations

Apr 8, 2004·Biological Research for Nursing·Marguerite Littleton-Kearney, Patricia D Hurn
Oct 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Shaolong YangIrshad H Chaudry
Aug 2, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ya-Ching HsiehIrshad H Chaudry
Sep 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ya-Ching HsiehIrshad H Chaudry
Jan 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul R CrisostomoDaniel R Meldrum
May 4, 2006·American Journal of Physiology. Endocrinology and Metabolism·Daniel I SprattCalvin P H Vary
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·D JarrarI H Chaudry
Sep 2, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michael P Muehlenbein, Richard G Bribiescas
Nov 20, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zheng F BaIrshad H Chaudry
Dec 20, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Huang-Ping YuIrshad H Chaudry
Mar 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rinki RayDaniel R Meldrum
Apr 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Daniel I SprattChristopher Longcope
Dec 1, 2007·Journal of Addiction Medicine·Rinah T YamamotoMarc J Kaufman
May 20, 2014·BioMed Research International·Figueroa-Valverde LauroVelázquez-Sarabia Betty Monica
Feb 8, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Zheng F BaIrshad H Chaudry
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zheng F BaIrshad H Chaudry
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Z F BaI H Chaudry
Oct 23, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hiroshi HommaEdwin A Deitch
Feb 11, 2005·Intensive Care Medicine·Gabriel MalerbaPierre-Edouard Bollaert
Sep 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jureta W HortonDavid L Maass
Sep 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Meijing WangDaniel R Meldrum
May 15, 2004·The Journal of Experimental Biology·Richard S Farrar, Kenneth J Rodnick

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