Testosterone recovery after prolonged androgen suppression in patients with prostate cancer

The Journal of Urology
Frederick H YoonRichard Choo

Abstract

We prospectively examined the extent and timing of testosterone recovery in patients with prostate cancer treated with 2 years of androgen suppression. A total of 153 patients with pT3N0M0 prostate cancer or positive margins after radical prostatectomy, or with prostate specific antigen relapse were treated with radiation to the prostate bed plus 2 years of androgen suppression as per a phase II study. Androgen suppression consisted of nilutamide for 4 weeks plus busereline acetate bimonthly for 2 years. Serum testosterone was measured at baseline, every 4 months during androgen suppression and every 6 months after androgen suppression during followup. Testosterone recovery to supracastrate levels, and to baseline and/or normal levels was estimated using Kaplan-Meier methods. Prognostic factors for testosterone recovery were examined. A total of 121 patients who completed 2 years of androgen suppression and 20 patients who received shorter durations of androgen suppression (median 16 months) were available for testosterone recovery analysis. Median followup after finishing androgen suppression was 38.9 months. All patients achieved castrate levels on androgen suppression. At 36 months after completion of androgen suppression 93...Continue Reading

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Citations

Jun 2, 2011·Nature Reviews. Urology·Lucas P Nacusi, Donald J Tindall
Feb 15, 2013·The Journal of Sexual Medicine·Landon W TrostWayne J G Hellstrom
Sep 19, 2012·Seminars in Radiation Oncology·Ronald C ChenBryce B Reeve
Dec 9, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin T NeadNigam H Shah
Jan 19, 2011·Nature Reviews. Urology·Fernand Labrie
Jul 18, 2019·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·A VallatJ Irani
Jun 5, 2021·International Journal of Clinical Oncology·Kazuhiro MatsumotoMototsugu Oya

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