PMID: 2110048Jan 1, 1990Paper

Testosterone reduces the bioactivity of luteinizing hormone (LH) in man

Clinical Endocrinology
A TsatsoulisW R Robertson

Abstract

The effect of testosterone on LH bioactivity was investigated in six adult men (aged 40-56 years) with primary hypogonadism. Two men received a 400 mg testosterone implant, another two 800 mg, and the final two patients received both doses in consecutive courses separated by at least 4 weeks. Plasma samples, obtained before and at 1, 2, 4, 8, 16 and 24 weeks after treatment, were analysed for bioactive LH by the mouse Leydig cell bioassay, and immunoreactive LH and testosterone (T) by standard radioimmunoassays. The bioactive to immunoreactive (B:I) LH ratio, an index of LH biopotency, was calculated and the results compared with those from a group (n = 17) of healthy adult men. Before treatment, both bioactive and immunoreactive LH levels in the patients were higher and T levels lower than in the normal men (P less than 0.001). The mean +/- SD B:I LH ratio (3.5 +/- 0.6) in the patients was greater (P less than 0.05) than in the controls (2.7 +/- 0.7), indicating that in primary testicular failure, increased amounts of LH with enhanced bioactivity are secreted. Following T administration, a dose-related increase in circulating T and a reciprocal decrease in LH levels was observed between 1 and 16 weeks of treatment. However, th...Continue Reading

References

May 3, 1979·The New England Journal of Medicine·A W LuckyJ Helke
Dec 1, 1987·Clinical Endocrinology·A TsatsoulisW R Robertson
Apr 1, 1988·The Journal of Clinical Investigation·R J UrbanM L Dufau
Feb 1, 1987·Baillière's Clinical Endocrinology and Metabolism·M L Dufau, J D Veldhuis
Sep 1, 1987·The Journal of Clinical Investigation·J D Veldhuis, M L Dufau
Aug 1, 1987·Clinical Endocrinology·W R RobertsonN Loveridge
Apr 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A M Matsumoto, W J Bremner
Mar 22, 1980·British Medical Journal·M H Thom, J W Studd
May 1, 1980·Endocrinology·P M ConnL Shoenhardt

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Citations

Oct 13, 2007·International Journal of Andrology·Anne Cailleux-BounacerJean Marc Kuhn
Sep 1, 1991·Clinical Endocrinology·A TsatsoulisW R Robertson

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