Testosterone Replacement Therapy for Sexual Symptoms

Sexual Medicine Reviews
Giulia RastrelliG Corona

Abstract

Several data have clearly shown that the endocrine system-and androgens in particular-play a pivotal role in regulating all the steps involved in the male sexual response cycle. Accordingly, testosterone (T) replacement therapy (TRT) represents a cornerstone of pharmacologic management of hypogonadal subjects with erectile dysfunction. The aim of this review is to summarize all the available evidence supporting the role of T in the regulation of male sexual function and to provide a comprehensive summary regarding the sexual outcomes of TRT in patients complaining of sexual dysfunction. A comprehensive PubMed literature search was performed. Specific analysis of preclinical and clinical evidence on the role of T in regulating male sexual function was performed. In addition, available evidence supporting the role of TRT on several sexual outcomes was separately investigated. T represents an important modulator of male sexual response function. However, the role of T in sexual functioning is less evident in epidemiologic studies because other factors, including organic, relational, and intrapsychic determinants, can orchestrate their effect independently from the state of androgens. Nonetheless, it is clear that TRT can ameliorat...Continue Reading

Citations

Jul 4, 2019·Journal of Endocrinological Investigation·A SansoneF Romanelli
Mar 21, 2020·Expert Review of Cardiovascular Therapy·G CoronaM Maggi
May 8, 2020·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Nov 3, 2020·Climacteric : the Journal of the International Menopause Society·D Boomsma, G Lahoud
Mar 24, 2020·Sexual Medicine·Omer Faruk KirlangicSerap Gur
Mar 23, 2021·International Journal of Impotence Research·G CoronaM Maggi
Jul 9, 2020·Sexual Medicine Reviews·Kelly PayneAlexander W Pastuszak
Aug 11, 2020·Practical Radiation Oncology·David G Wallington, Emma B Holliday
Jun 30, 2021·European Urology·Andrea SaloniaUNKNOWN EAU Working Group on Male Sexual and Reproductive Health
Jun 26, 2021·The World Journal of Men's Health·Giovanni CoronaMario Maggi

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