Testosterone Replacement Therapy: Long-Term Safety and Efficacy

The World Journal of Men's Health
G CoronaMario Maggi

Abstract

Recent position statements and guidelines have raised the distinction between a true and false, age-related hypogonadism (HG) or late-onset hypogonadism (LOH). The former is the consequence of congenital or acquired "organic" damage of the brain centers or of the testis. The latter is mainly secondary to age-related comorbidities and does not require testosterone (T) therapy (TTh). In addition, concerns related to cardiovascular (CV) safety have further increased the scepticism related to TTh. In this paper, we reviewed the available evidence supporting the efficacy of TTh in non-organic HG and its long term safety. A large amount of evidence has documented that sexual symptoms are the most specific correlates of T deficiency. TTh is able to improve all aspects of sexual function independent of the pathogenetic origin of the disease supporting the scientific demonstration that LOH does exist according to an "ex-juvantibus" criterion. Although the presence of metabolic derangements could mitigate the efficacy of TTh on erectile dysfunction, the positive effect of TTh on body composition and insulin sensitivity might counterbalance the lower efficacy. CV safety concerns related to TTh are essentially based on a limited number of ...Continue Reading

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Citations

Aug 14, 2018·Expert Review of Cardiovascular Therapy·Giulia RastrelliGiovanni Corona
Jun 28, 2019·International Journal of Impotence Research·Afonso MorgadoCarlos Martins Silva
Aug 20, 2020·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Mar 6, 2018·Expert Review of Clinical Pharmacology·Giulia RastrelliGiovanni Corona
Apr 27, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ali Cift, Mehmet Ozgur Yucel
May 1, 2018·The World Journal of Men's Health·Jonathan Clavell-Hernández, Run Wang
May 8, 2020·The World Journal of Men's Health·Giovanni CoronaMario Maggi
Oct 22, 2018·Journal of Endocrinological Investigation·F ColuzziG Corona
Nov 20, 2019·Clinical and Experimental Reproductive Medicine·Seung-Hun SongDong Suk Kim
May 13, 2018·International Journal of Environmental Research and Public Health·James Jam JollyIma Nirwana Soelaiman
Feb 1, 2019·Journal of Clinical Medicine·Min Gu ParkDu Geon Moon
Feb 10, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcelo Langer Wroclawski, Flavio Lobo Heldwein
Jun 5, 2021·Expert Review of Clinical Pharmacology·Giovanni CoronaMario Maggi
Jun 26, 2021·The World Journal of Men's Health·Giovanni CoronaMario Maggi

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