Testosterone Replacement Therapy Prevents Alterations of Coronary Vascular Reactivity Caused by Hormone Deficiency Induced by Castration

PloS One
Wender Nascimento RouverMargareth R Moysés

Abstract

The present study aimed to determine the effects of chronic treatment with different doses of testosterone on endothelium-dependent coronary vascular reactivity in male rats. Adult male rats were divided into four experimental groups: control (SHAM), castrated (CAST), castrated and immediately treated subcutaneously with a physiological dose (0.5 mg/kg/day, PHYSIO group) or supraphysiological dose (2.5 mg/kg/day, SUPRA group) of testosterone for 15 days. Systolic blood pressure (SBP) was assessed at the end of treatment through tail plethysmography. After euthanasia, the heart was removed and coronary vascular reactivity was assessed using the Langendorff retrograde perfusion technique. A dose-response curve for bradykinin (BK) was constructed, followed by inhibition with 100 μM L-NAME, 2.8 μM indomethacin (INDO), L-NAME + INDO, or L-NAME + INDO + 0.75 μM clotrimazole (CLOT). We observed significant endothelium-dependent, BK-induced coronary vasodilation, which was abolished in the castrated group and restored in the PHYSIO and SUPRA groups. Furthermore, castration modulated the lipid and hormonal profiles and decreased body weight, and testosterone therapy restored all of these parameters. Our results revealed an increase in S...Continue Reading

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Citations

Nov 27, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Mercedes PerusquíaJohn N Stallone
Nov 6, 2018·Journal of Bone and Mineral Metabolism·Forough SakiGholam Hossein Ranjbar Omrani
May 19, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Wender do Nascimento RouverRoger Lyrio Dos Santos

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

PHYSIO
GraphPad Prism
CAST
SUPRA
SHAM

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