Testosterone-Secreting Ovarian Tumor: A Rare Cause of Erythrocytosis and Pulmonary Embolus.

AACE Clinical Case Reports
Naomi FriedmanJason A Sternchos

Abstract

To raise awareness of the clinical presentation of a testosterone-secreting steroid cell tumor, not otherwise specified, causing pulmonary embolus (PE) and erythrocytosis. Report of the first known case of ovarian steroid cell tumor not otherwise specified leading to PE. A 67-year-old Caucasian postmenopausal woman was referred for endocrine evaluation of a 1-year history of hirsutism, weight gain, and elevated total testosterone level of 672 ng/dL (normal, <75 ng/dL). She reported increased hair growth on her chin for the past year, unintentional weight gain, and low energy levels. Laboratory data from the initial visit included a total testosterone level of 672 ng/dL (normal, <75 ng/dL), hemoglobin level of 18.0 g/dL (normal, 11.7-15 g/dL), and hematocrit level of 50.4% (normal, 35%-45%). Four months after initial presentation, the patient developed acute-onset chest pain and shortness of breath and was diagnosed with a right PE on computed tomography chest angiogram. Evaluation with imaging for an ovarian mass revealed a negative workup including computed tomography abdomen pelvis, transvaginal ultrasound, and pelvic magnetic resonance imaging. Despite negative findings during imaging, because of the markedly elevated testos...Continue Reading

References

Nov 1, 1987·The American Journal of Surgical Pathology·M C Hayes, R E Scully
Jun 9, 2010·The Journal of Clinical Endocrinology and Metabolism·M Mercè Fernández-BalsellsVictor M Montori
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Eric BachmanShalender Bhasin
Oct 25, 2013·The Journal of Clinical Endocrinology and Metabolism·Pinar KozanBronwyn A Crawford
Jan 21, 2017·Molecular and Clinical Oncology·Lili QianYing Zhou

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