Testosterone Supplementation and Cognitive Functioning in Men-A Systematic Review and Meta-Analysis

Journal of the Endocrine Society
Cecilie R BuskbjergRobert Zachariae

Abstract

Testosterone supplementation (TS) is assumed important for cognitive functioning in men, but conflicting results have prevented firm conclusions. The current study systematically reviewed available randomized controlled trials (RCTs) on effects of TS on cognitive functioning in men, subjected the findings to meta-analysis, and explored between-study differences as possible moderators of the effects. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, two authors independently searched for eligible records in the electronic databases of PubMed, PsycINFO, Web of Science, the Cochrane Library, Cumulative Index of Nursing and Allied Health, and Embase and determined eligibility using the following (population, intervention, comparison, outcome) criteria: population, male adults (>18 years); intervention, TS; comparison, placebo; and outcome, results of standardized neuropsychological tests. Following duplicate removal, 3873 records were screened with 92 remaining for full-text screening. Twenty-one papers reporting results of 23 independent RCTs were included, of which none treated samples of clinically hypogonadal men. The small improvement found in overall cognitive functioning (Hedges g =...Continue Reading

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Citations

Sep 24, 2019·Endocrine Reviews·Elisabetta VegetoAngelo Poletti
Feb 15, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M T FerrettiR Schmidt
May 30, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Anne SkakkebaekMikkel Wallentin
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Oct 24, 2020·Journal of the Endocrine Society·Vittorio Emanuele BianchiAntonio Torsello
Dec 29, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Nicholas A DeebelHooman Sadri-Ardekani

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Methods Mentioned

BETA
pharmacotherapy
Assay

Software Mentioned

SPSS
Comprehensive Meta - Analysis

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