Abstract
Men with congestive heart failure (CHF) have relatively low testosterone levels. Several studies demonstrated that testosterone treatment increases cardiac output and reduces peripheral vascular resistance. However, the effects of testosterone on heart function, cardiomyocyte apoptosis and ventricular remodeling have not been fully elucidated. This study was conducted to investigate the effects of testosterone on heart function, cardiomyocyte apoptosis and ventricular remodeling in male rats post-myocardial infarction. A total of 86 male rats were randomly assigned to undergo ligation of the coronary artery (n=70) or pseudosurgery (n=16). After 6 weeks, a left ventricular ejection fraction (LVEF) of ≤45% was defined as a successful model of CHF. The model rats were randomly assigned to 3 groups, namely low-dose testosterone (TU), high-dose TU and placebo (PL) groups. After treatment for 12 weeks, the expression of several mRNA transcripts in myocardial tissue was measured by quantitative polymerase chain reaction. Immunofluorescence was used to measure myocardial caspase-3 expression. Compared to the PL group, LVEF was significantly improved in the TU treatment groups. Moreover, the mRNA expression of atrial natriuretic peptide...Continue Reading
References
Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·P NoirhommeR Dion
Feb 1, 2000·Biochemical and Biophysical Research Communications·T PelzerL Neyses
May 12, 2000·British Journal of Pharmacology·M M MocanuD M Yellon
Jul 6, 2000·The Journal of Clinical Investigation·A DucharmeR T Lee
Oct 13, 2000·QJM : Monthly Journal of the Association of Physicians·P J PughK S Channer
Apr 5, 2001·European Heart Journal·J G ClelandA Clark
Dec 31, 2002·Cardiovascular Research·Konrad F FrankRobert H G Schwinger
Feb 5, 2003·Cardiovascular Research·Matthias NahrendorfFrank Callies
Mar 8, 2003·Circulation Research·Atsushi SanbeJeffrey Robbins
Apr 26, 2003·European Heart Journal·Peter J PughKevin S Channer
Mar 17, 2004·Heart·P J PughK S Channer
Mar 24, 2004·Circulation·Ying ChenJean-Jacques Mercadier
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Chris J MalkinT Hugh Jones
Aug 12, 2005·European Heart Journal·Chris J MalkinKevin S Channer
Dec 31, 2005·Journal of Cardiovascular Pharmacology and Therapeutics·Marta RubioArnold Schwartz
Oct 13, 2006·Circulation·Ewa A JankowskaPiotr Ponikowski
Sep 1, 2007·Journal of Hypertension·Susana CavalleroBelisario E Fernández
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yan-Zhou ZhangLe-Xin Wang
Apr 16, 2011·Journal of the American College of Cardiology·David J HollandThomas H Marwick
Citations
Apr 11, 2018·Canadian Journal of Physiology and Pharmacology·Tomas BakaFedor Simko
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Sonnet S JonkerCharles E Roselli
Apr 14, 2017·Physiology·Yoginee SritharenJordan D Miller
Aug 4, 2018·Current Diabetes Reviews·Mortaza F Hassanabad, Mohammad Fatehi
Oct 26, 2018·Circulation Research·Jun-Ming TangShi-You Chen
Jan 2, 2018·Maturitas·Vinita SubramanyaErin D Michos
Feb 25, 2019·The American Journal of the Medical Sciences·Ming ShenZhi-Fu Guo
Jul 23, 2021·Cardiovascular Research·Antonio CittadiniAndrea Salzano