Testosterone suppresses ventricular remodeling and improves left ventricular function in rats following myocardial infarction

Experimental and Therapeutic Medicine
Xiao-Fei WangJun-Feng Zhang

Abstract

Men with congestive heart failure (CHF) have relatively low testosterone levels. Several studies demonstrated that testosterone treatment increases cardiac output and reduces peripheral vascular resistance. However, the effects of testosterone on heart function, cardiomyocyte apoptosis and ventricular remodeling have not been fully elucidated. This study was conducted to investigate the effects of testosterone on heart function, cardiomyocyte apoptosis and ventricular remodeling in male rats post-myocardial infarction. A total of 86 male rats were randomly assigned to undergo ligation of the coronary artery (n=70) or pseudosurgery (n=16). After 6 weeks, a left ventricular ejection fraction (LVEF) of ≤45% was defined as a successful model of CHF. The model rats were randomly assigned to 3 groups, namely low-dose testosterone (TU), high-dose TU and placebo (PL) groups. After treatment for 12 weeks, the expression of several mRNA transcripts in myocardial tissue was measured by quantitative polymerase chain reaction. Immunofluorescence was used to measure myocardial caspase-3 expression. Compared to the PL group, LVEF was significantly improved in the TU treatment groups. Moreover, the mRNA expression of atrial natriuretic peptide...Continue Reading

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Citations

Apr 11, 2018·Canadian Journal of Physiology and Pharmacology·Tomas BakaFedor Simko
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Sonnet S JonkerCharles E Roselli
Apr 14, 2017·Physiology·Yoginee SritharenJordan D Miller
Aug 4, 2018·Current Diabetes Reviews·Mortaza F Hassanabad, Mohammad Fatehi
Feb 25, 2019·The American Journal of the Medical Sciences·Ming ShenZhi-Fu Guo
Jul 23, 2021·Cardiovascular Research·Antonio CittadiniAndrea Salzano

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Methods Mentioned

BETA
PCR

Software Mentioned

Pro Plus
Image
SPSS
Vecter NTI

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