Testosterone therapy in premenopausal women

Seminars in Reproductive Medicine
Sophia N Kalantaridou, Karim A Calis

Abstract

Testosterone therapy for postmenopausal women and women with surgical menopause, albeit controversial, is becoming more widespread. However, only limited data are available to support its use in premenopausal women. Androgens have important biological roles in young women, influencing bone and muscle mass, mood and well-being, and libido. Pathophysiological states affecting ovarian and adrenal function or both may result in androgen deficiency in premenopausal women. Young women with hypothalamic amenorrhea, premature ovarian failure, oophorectomy, premenstrual syndrome, acquired immunodeficiency wasting syndrome, adrenal insufficiency, and hypopituitarism may have testosterone deficiency. Young women with loss of libido may also have testosterone deficiency. Medications that may lead to testosterone insufficiency include oral estrogen, oral contraceptives, and corticosteroids. Testosterone deficiency in young women may be underdiagnosed because the symptoms generally are nonspecific and the measurement of total and free testosterone is inaccurate with commonly used techniques. Only a few studies investigating the effects of testosterone therapy have been performed thus far in premenopausal women. Long-term trials evaluating sa...Continue Reading

Citations

Jan 1, 2008·Journal of Multidisciplinary Healthcare·Enrique GinzburgAlan Mintz
Dec 26, 2012·Maturitas·Rebecca GlaserConstantine Dimitrakakis
Aug 6, 2011·Clinical Journal of Oncology Nursing·Tiffany A RichardsUNKNOWN International Myeloma Foundation Nurse Leadership Board
Aug 5, 2016·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Chien-Yu ChenChieh-Hsin Lin
May 27, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Arif Kokcu

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