Testosterone treatment and cardiovascular and venous thromboembolism risk: what is 'new'?

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
G CoronaM Maggi

Abstract

In men, testosterone (T) production declines as a function of ageing. Late-onset hypogonadism (LOH) is the most commonly used term to indicate this age-related condition. In LOH, the relative clinical significance and the potential benefit of testosterone treatment (TTh) are still the subject of strong criticisms in the scientific community. The debate is further complicated by the recent position statement of the US Food and Drug Administration (FDA) emphasizing that, in LOH, the benefits and safety of TTh have not been fully established. Hence, the FDA required a labeling change to inform patients about a possible increased cardiovascular (CV) risk of TTh. Similar considerations were previously released by the FDA and by Health Canada concerning a TTh-related venous thromboembolism (VTE) risk. In this review, we will summarize the available evidence concerning a possible link among TTh and CV and VTE risks. For this purpose, data derived from epidemiological studies analyzing relationships between the aforementioned risks and endogenous T levels will be analyzed. In addition, evidence deriving from interventional studies including pharmacoepidemiological and placebo-controlled randomized controlled trials (RCTs) will be exami...Continue Reading

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Citations

Dec 19, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Charles J GlueckPing Wang
Aug 14, 2018·Expert Review of Cardiovascular Therapy·Giulia RastrelliGiovanni Corona
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Jan 14, 2020·The Journal of Sexual Medicine·Giovanni CoronaMario Maggi
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Jun 15, 2021·Curēus·Kevin ThompsonOlu Oyesanmi
Aug 17, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Bruno LunenfeldAbraham Morgentaler

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