Testosterone undecanoate in the treatment of male hypogonadism

Expert Opinion on Pharmacotherapy
Daniel Edelstein, Shehzad Basaria

Abstract

Testosterone undecanoate (TU) represents an exciting new testosterone replacement therapy for hypogonadal men due to its convenient dosing schedule and favorable pharmacokinetic and safety profiles. Clinical, pharmacokinetic and safety characteristics of TU will be reviewed. The characteristics of currently approved testosterone therapies will be reviewed and compared with those of TU in order to determine which therapy most appropriately meets the clinical objective of properly matching a patient with a therapy that is best able to deliver physiological levels of testosterone for prolonged periods of time, while at the same time being safe, effective, inexpensive, simple to use, and with few side effects. TU represents the first long-acting injectable with an excellent safety profile that can be administered only four times annually to produce stable levels of testosterone. Long-term studies have validated the clinical efficacy of TU in maintaining therapeutic levels of testosterone. Patient preference for the convenient dosing schedule might also lead to better compliance and therapeutic benefit. No serious side effects have been noted with the use of TU, including long-term data on patients treated with TU over 8 years. TU i...Continue Reading

References

Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·W J BremnerP N Prinz
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·S M HarmanUNKNOWN Baltimore Longitudinal Study of Aging
May 10, 2001·The American Journal of Medicine·S Basaria, A S Dobs
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·John K AmoryJ Lisa Tenover
Aug 27, 2004·Drugs·Louis J G Gooren, Mathijs C M Bunck
Aug 10, 2005·Expert Opinion on Pharmacotherapy·Lindsey HarleAdrian S Dobs
Aug 13, 2005·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·E NieschlagF C W Wu
Dec 24, 2005·Asian Journal of Andrology·Louis J G Gooren, Farid Saad
May 10, 2006·The Journal of Sexual Medicine·Abdulmaged M Traish, André T Guay
Aug 19, 2007·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·T MinnemannF Jockenhövel
Feb 2, 2010·Asian Journal of Andrology·Gideon SartoriusDavid J Handelsman

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Citations

Jun 5, 2012·Rejuvenation Research·Pierre Olivier LangNikolaos Samaras
Aug 1, 2014·Expert Opinion on Pharmacotherapy·Giovanni CoronaMario Maggi
Aug 14, 2013·The Journal of Sexual Medicine·Stefan ArverElvira Müller
Apr 5, 2016·International Journal of Pharmaceutics·R W KalicharanH Vromans
Oct 17, 2012·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Bruno LunenfeldHeinrich M Schulte
Jun 28, 2011·Molecular and Cellular Endocrinology·Bernard Haendler, Arwed Cleve
Jan 28, 2014·Korean journal of urology·Jane AshbyHossein Sadeghi-Nejad
Aug 24, 2016·Expert Opinion on Emerging Drugs·Aydogan Aydogdu, Ronald S Swerdloff
Sep 30, 2020·Expert Review of Endocrinology & Metabolism·James Christopher John Prince, Joshua D Safer
Dec 10, 2020·Journal of the Endocrine Society·Maria VogiatziAlan D Rogol
Apr 20, 2021·Expert Opinion on Pharmacotherapy·Eliyahu KreschRanjith Ramasamy

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