TET enzymes, TDG and the dynamics of DNA demethylation

Nature
Rahul M Kohli, Yi Zhang

Abstract

DNA methylation has a profound impact on genome stability, transcription and development. Although enzymes that catalyse DNA methylation have been well characterized, those that are involved in methyl group removal have remained elusive, until recently. The transformative discovery that ten-eleven translocation (TET) family enzymes can oxidize 5-methylcytosine has greatly advanced our understanding of DNA demethylation. 5-Hydroxymethylcytosine is a key nexus in demethylation that can either be passively depleted through DNA replication or actively reverted to cytosine through iterative oxidation and thymine DNA glycosylase (TDG)-mediated base excision repair. Methylation, oxidation and repair now offer a model for a complete cycle of dynamic cytosine modification, with mounting evidence for its significance in the biological processes known to involve active demethylation.

References

Nov 1, 1973·Archives of Biochemistry and Biophysics·C K LiuM T Abbott
Feb 1, 1972·The Biochemical Journal·N W PennR Yura
Feb 17, 2000·Nature·W MayerThomas Haaf
May 10, 2000·Current Biology : CB·J OswaldJ Walter
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Edmund WongWinfried Edelmann
Dec 14, 2004·Advances in Protein Chemistry·J Christopher Fromme, Gregory L Verdine
Jun 15, 2005·Annual Review of Biochemistry·Mary Grace Goll, Timothy H Bestor
Aug 25, 2005·Cold Spring Harbor Symposia on Quantitative Biology·Timothy H Bestor, D Bourc'his
Jan 13, 2006·Trends in Biochemical Sciences·Robert J Klose, Adrian Bird
Sep 21, 2006·Journal of the American Chemical Society·Matthew T BennettAlexander C Drohat
Nov 23, 2006·DNA Repair·Daniel CortázarPrimo Schär
Mar 7, 2008·Nature·Raphaël MétivierGilles Salbert
Mar 7, 2008·Nature·Sara KangaspeskaGeorge Reid
Mar 29, 2008·PLoS Genetics·Seung-Gi JinGerd P Pfeifer
Jul 1, 2008·Cell·Steen K T Ooi, Timothy H Bestor
Aug 30, 2008·Annual Review of Microbiology·Piet Borst, Robert Sabatini
Jan 16, 2009·Trends in Genetics : TIG·Mary GehringSteven Henikoff
Apr 18, 2009·Science·Skirmantas Kriaucionis, Nathaniel Heintz
May 12, 2009·Nature Chemical Biology·Zita LiutkeviciuteSaulius Klimasauskas
May 29, 2009·The New England Journal of Medicine·Francois DelhommeauOlivier A Bernard
Jun 2, 2009·Nature Genetics·Saskia M C LangemeijerJoop H Jansen
Aug 8, 2009·Annual Review of Genetics·Jian-Kang Zhu
May 6, 2010·The EMBO Journal·Mark WossidloJörn Walter
Jun 17, 2010·Nature Reviews. Clinical Oncology·Alfonso Quintás-CardamaGuillermo Garcia-Manero
Aug 5, 2010·Nature Reviews. Molecular Cell Biology·Susan C Wu, Yi Zhang
Aug 24, 2010·Trends in Biochemical Sciences·Christoph Loenarz, Christopher J Schofield
Dec 9, 2010·Cold Spring Harbor Symposia on Quantitative Biology·M Azim Surani, Petra Hajkova
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Khursheed IqbalPiroska E Szabó
Mar 17, 2011·Nature Communications·Mark WossidloJörn Walter
Apr 15, 2011·Nature·Kristine WilliamsKristian Helin
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Myunggon KoAnjana Rao
Sep 3, 2011·Cell Stem Cell·Luisa CimminoIannis Aifantis
Sep 20, 2011·Cell·Nidhi BhutaniHelen M Blau
Sep 24, 2011·Nature Reviews. Cancer·Stephen B Baylin, Peter A Jones
Feb 14, 2012·Nature Chemical Biology·Liang ZhangChuan He
Feb 22, 2012·Trends in Cell Biology·Christof Niehrs, Andrea Schäfer
Mar 6, 2012·Trends in Genetics : TIG·Jamie A HackettM Azim Surani
Mar 30, 2012·Nature·Zachary D SmithAlexander Meissner
Jul 10, 2012·Nature Chemical Biology·Christopher S NabelRahul M Kohli
Aug 24, 2012·PloS One·Gopinath RangamSvend K Petersen-Mahrt
Aug 28, 2012·Epigenomics·Shannon R Dalton, Alfonso Bellacosa
Oct 2, 2012·Frontiers in Genetics·Timothy G Jenkins, Douglas T Carrell
Nov 10, 2012·Nature Biotechnology·Chun-Xiao SongChuan He
Nov 16, 2012·Nature·Shinpei YamaguchiYi Zhang
Dec 12, 2012·Molecular Cell·Stefanie SeisenbergerWolf Reik
Dec 18, 2012·The EMBO Journal·Saya KagiwadaMitinori Saitou
Jan 23, 2013·Journal of Molecular Biology·Hideharu HashimotoXiaodong Cheng
Feb 19, 2013·Cell Stem Cell·John J VincentAmander T Clark
Feb 26, 2013·Cell·Cornelia G SpruijtMichiel Vermeulen
Oct 25, 2013·Nature·Effie Apostolou, Konrad Hochedlinger

Citations

Sep 28, 2014·Current Osteoporosis Reports·Jonathan A R GordonJane B Lian
Apr 8, 2014·Genes·Albino BacollaKaren M Vasquez
Mar 8, 2014·Nature Reviews. Immunology·Andrew D Wells, Peter A Morawski
Jun 7, 2014·Annual Review of Biochemistry·Li ShenYi Zhang
Mar 26, 2014·Nature Reviews. Genetics·Ye FuChuan He
Jan 10, 2014·Stem Cells and Development·Wenjia SunXuekun Li
Jul 1, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jonathan J LeeChristine G Lian
Sep 4, 2014·High Altitude Medicine & Biology·Carolyn J Brown, James L Rupert
Sep 10, 2014·Annual Review of Genetics·Emily Brookes, Yang Shi
Nov 21, 2014·Nature Chemistry·Martin BachmanShankar Balasubramanian
Sep 4, 2014·European Journal of Clinical Nutrition·M J Dauncey
Oct 24, 2014·Biology·Vichithra R B LiyanageJames R Davie
Feb 11, 2016·Journal of Clinical Medicine·Shih-Han KaoWen-Hwa Lee
Feb 5, 2016·ACS Chemical Biology·Wolfgang Fischle, Dirk Schwarzer
Jan 12, 2016·Nature Structural & Molecular Biology·Lars SchomacherChristof Niehrs
Jul 19, 2014·Nucleic Acids Research·Stephen J RoperMyriam Hemberger
Jul 23, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jinsuk KangAnjana Rao
Nov 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lukas ChavezAnjana Rao
May 21, 2015·Kidney International·Marpadga A Reddy, Rama Natarajan
Jan 7, 2016·Frontiers in Behavioral Neuroscience·Jose V Sanchez-Mut, Johannes Gräff
Sep 16, 2015·Acta Biochimica Et Biophysica Sinica·Xuehe XuChunming Liu
Dec 25, 2015·Nature·William A FlavahanBradley E Bernstein
Jan 23, 2016·Stem Cells International·Christian Kosan, Maren Godmann
Jul 19, 2015·Neuro-oncology·Matthew S WaitkusHai Yan
Nov 1, 2015·Nucleic Acids Research·Nicholas C BauerPaul W Doetsch
Dec 24, 2015·Stem Cells International·Rubén Fernández-Santiago, Mario Ezquerra
Jul 26, 2015·Histochemistry and Cell Biology·Hirotaka YoshiokaYuji Yoshiko
Mar 17, 2016·Animal Biotechnology·Chien-Hong ChenChin-kai Chuang
Mar 24, 2016·Cell Biochemistry and Function·Amr Rafat Elhamamsy
Sep 1, 2015·Cell Research·Jian-Huang Xue, Guo-Liang Xu
Nov 25, 2015·Future Microbiology·Alison J EastmanMichal A Olszewski
Sep 12, 2015·Annual Review of Cell and Developmental Biology·Ryan JankeJasper Rine
Oct 7, 2015·Frontiers in Immunology·Bharat Vaidyanathan, Jayanta Chaudhuri
Oct 6, 2015·Fibrogenesis & Tissue Repair·Roisin NearyJohn A Baugh
Sep 16, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Tasnim Dayeh, Charlotte Ling
Sep 4, 2015·Nature Structural & Molecular Biology·Hasan Yardimci, Yi Zhang
Aug 26, 2015·Journal of the American Chemical Society·Thomas F Brewer, Christopher J Chang
Jul 16, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Takehito SawamuraRaül Andero
Jul 19, 2015·Journal of Molecular Cell Biology·Ning DingHeather M O'Hagan
Jun 3, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Chelsea MarchoJesse Mager
May 15, 2015·Annual Review of Nutrition·Juan I YoungGaofeng Wang
Jul 11, 2015·Database : the Journal of Biological Databases and Curation·Yulia A MedvedevaFinn Drabløs
May 23, 2015·Nature Reviews. Drug Discovery·Moshe Szyf
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chi V Dang
Jun 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eric B KeverneInna Tabansky
Mar 31, 2015·Mediators of Inflammation·Rehana YasminNafees Ahmad
Aug 26, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Andrey PoleshkoRichard A Katz
Jan 13, 2015·Cellular and Molecular Life Sciences : CMLS·Cécile VrietChristophe Laloi
Dec 30, 2014·Frontiers in Neuroscience·Sahar Al-MahdawiMark A Pook
Jan 8, 2015·Frontiers in Immunology·Pilar M Dominguez, Rita Shaknovich
Oct 24, 2014·Annual Review of Entomology·Hua YanDanny Reinberg
Dec 23, 2014·Epigenomics·Aliya Mari D AdefuinMasakazu Namihira
Nov 29, 2014·Epigenomics·Euan J RodgerIan M Morison
Jun 9, 2016·Nutrition and Cancer·Fernando Salvador MorenoIgor P Pogribny
Feb 8, 2014·BioTechniques·Steven R HeadPhillip Ordoukhanian
Jul 7, 2016·Epigenomics·Hon-Sum Jeffrey ManPhilip A Marsden
Jul 9, 2016·Connective Tissue Research·Jie ShenAudrey McAlinden
Jul 10, 2016·Cellular and Molecular Life Sciences : CMLS·Lidong Sun, Jia Fang
Jul 15, 2016·Chinese Medical Journal·Yi-Ping TianMaode Lai
May 26, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Petra Sipilä, Ida Björkgren
Aug 9, 2016·The Journal of Clinical Investigation·Linya YouXiang-Jiao Yang
Aug 9, 2016·Chemical Reviews·Alexander C Drohat, Christopher T Coey
Aug 16, 2016·Briefings in Functional Genomics·Hongbo LiuYan Zhang
Sep 15, 2016·Epigenomics·Wolfgang A Schulz, Wolfgang Goering
Jul 28, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Renu A KowluruManish Mishra
Oct 1, 2016·Development and Psychopathology·Tiffany S Doherty, Tania L Roth
Oct 14, 2016·Epigenomics·Moshe Szyf
Nov 9, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Thanh V HoangMichael L Robinson
Dec 6, 2016·Nature Chemical Biology·Monica Yun LiuRahul M Kohli
Dec 6, 2016·International Neurourology Journal·Hong-Tao LiGangning Liang
Jan 28, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Ligia A PapaleReid S Alisch
Mar 8, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Lara C LewisAlexey Ruzov
Oct 4, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Yonatan Stelzer, Rudolf Jaenisch
Feb 22, 2017·Genes·Sabine A S LangieJohn C Mathers
Apr 12, 2017·Scientific Data·Antonio PezoneEnrico V Avvedimento
Mar 24, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jennifer BlazeTania L Roth
Feb 9, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Min Jee KwonSung Bae Lee
Aug 26, 2015·Biochimica Et Biophysica Acta·Rebecca L FarrMarc Fransen
Nov 29, 2016·Neurobiology of Disease·Maciej GrzybekPawel Lisowski
Jun 18, 2016·Current Opinion in Chemical Biology·Monica Yun LiuRahul M Kohli
Nov 23, 2016·Free Radical Biology & Medicine·Marco Seifermann, Bernd Epe
Jun 4, 2016·Molecular Cell·Alexey A SoshnevC David Allis
Jun 4, 2016·Molecular Cell·Jean-Pierre Etchegaray, Raul Mostoslavsky
May 31, 2017·Nature Reviews. Genetics·Xiaoji Wu, Yi Zhang
Apr 27, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dimitry A Chistiakov, Vladimir P Chekhonin
Jun 7, 2017·Nature Structural & Molecular Biology·Guan-Zheng Luo, Chuan He
Oct 16, 2016·Stem Cells·Agata StryjewskaDanny Huylebroeck
Apr 15, 2014·Cell and Tissue Research·Addie Kolybaba, Anne-Kathrin Classen
Sep 12, 2015·The Lancet. Psychiatry·Gustavo TureckiJoan Kaufman
Feb 28, 2017·Nature·Theodore T HoEmmanuelle Passegué
May 5, 2017·Nucleic Acids Research·Emily K SchutskyRahul M Kohli
Mar 8, 2017·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Keiko NoharaShota Takumi
Sep 13, 2015·Molecular & Cellular Proteomics : MCP·Yang YuYinsheng Wang
Nov 28, 2016·Trends in Genetics : TIG·Lin Liu
Dec 20, 2016·Cancer Science·Hideyuki TakeshimaToshikazu Ushijima
Jan 24, 2017·Asian-Australasian Journal of Animal Sciences·Minghui ZhaoSeunghoon Lee
Jun 8, 2017·Journal of Cellular Biochemistry·Jesús Rafael Rodríguez-AguileraVictoria Chagoya de Sánchez
Sep 2, 2014·Chemical Communications : Chem Comm·Gordon R McInroyShankar Balasubramanian
Jun 25, 2017·Current Opinion in Genetics & Development·Jaber Firas, Jose M Polo
Apr 30, 2015·Reproductive Sciences·Qiwei YangAyman Al-Hendy
Jul 19, 2017·Journal of the American Chemical Society·René RahimoffThomas Carell
Apr 29, 2015·Seminars in Cell & Developmental Biology·Jennifer Blaze, Tania L Roth
Jul 26, 2017·Journal of the American Chemical Society·Fengchao LiChuanzheng Zhou
Mar 13, 2018·Journal of Surgical Oncology·Anjing ZhongMaode Lai
Feb 1, 2018·European Journal of Clinical Investigation·Albert J Czaja
Sep 15, 2017·Physiological Reports·Bram PiersmaRuud A Bank
Aug 11, 2017·International Journal of Molecular Sciences·Tho X Pham, Ji-Young Lee
Mar 23, 2018·International Journal of Molecular Sciences·Jing SongLiang Jin
Apr 8, 2015·Nucleic Acids Research·Zheng LiGuo-Liang Xu
Jan 13, 2018·Annual Review of Public Health·Elizabeth M Martin, Rebecca C Fry
Feb 26, 2015·Nucleic Acids Research·Claudia N BuechnerIngrid Tessmer
Sep 15, 2017·Chemistry : a European Journal·Iacovos N MichaelidesThomas Carell
Apr 18, 2018·Chembiochem : a European Journal of Chemical Biology·Kosuke NishioHiroaki Suga
Jan 24, 2018·Nature Genetics·Julie DonagheyAlexander Meissner
Apr 26, 2018·Nucleosides, Nucleotides & Nucleic Acids·M LöfflerE Zameitat
Sep 28, 2017·Clinical Epigenetics·Sonia García-CalzónCharlotte Ling
Jan 10, 2018·Frontiers in Aging Neuroscience·Anna StarnawskaLene Christiansen
Jan 26, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jack S HardwickTom Brown
Oct 4, 2016·Genetics & Epigenetics·Wenyi XuFengjiao Xin
Oct 2, 2015·Therapeutic Advances in Musculoskeletal Disease·Adam CribbsUdo Oppermann
Jan 5, 2018·Clinical Epigenetics·Anneli C S BolundTorben Sigsgaard
Aug 5, 2017·Immunotherapy·Xuehui HeIrma Joosten
Jun 20, 2018·Wiley Interdisciplinary Reviews. RNA·Helena Covelo-MolaresStepanka Vanacova
Jul 3, 2018·Chemical Communications : Chem Comm·Richard J HopkinsonChristopher J Schofield
Sep 26, 2017·Environmental Toxicology and Chemistry·Susanne M BranderRichard E Connon
Oct 7, 2014·Journal of Cellular Physiology·Claire Marchal, Benoit Miotto
Sep 19, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Federico González, Danwei Huangfu
Oct 14, 2017·American Journal of Physical Anthropology·Christopher J ClukayConnie J Mulligan
Jul 22, 2016·Angewandte Chemie·Clemens MayerShankar Balasubramanian
Dec 6, 2017·Journal of Molecular Endocrinology·Louise Ruby Høj IllumAnders Lade Nielsen
Mar 7, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mariko AriyoshiMasahiro Shirakawa
Jan 30, 2018·Cellular & Molecular Immunology·Haijing WuQianjin Lu
Nov 24, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jianhui ZhuangWenhui Peng
Sep 13, 2014·Circulation Research·Ali J Marian
Oct 9, 2018·Nature Biotechnology·Emily K SchutskyRahul M Kohli
Oct 23, 2018·Investigative Ophthalmology & Visual Science·Arul J DuraisamyRenu A Kowluru
Feb 26, 2016·Nature Communications·Thuy T M NgoTaekjip Ha
Jan 1, 2015·F1000Research·Di ChenTianqian Hui
Nov 1, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Thangavel VaijayanthiHiroshi Sugiyama
Sep 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chengcheng JiChiung-Kuei Huang
Nov 10, 2018·Annual Review of Animal Biosciences·Constance E ClareKevin D Sinclair
Feb 21, 2018·Scientific Reports·Haolin LiuGongyi Zhang
Feb 27, 2019·Archives of Pharmacal Research·Jong Woo Park, Jeung-Whan Han
Jan 24, 2019·Stem Cells and Development·Nikola SobočanFloriana Bulić-Jakuš
Jan 17, 2019·Nucleic Acids Research·Christopher E SchlosbergJohn R Edwards
Feb 1, 2014·Journal of the American Society of Nephrology : JASN·Debra F Higgins, Madeline Murphy
Mar 22, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Chen Seng NgTakashi Fujita
May 16, 2015·Clinical Epigenetics·Christopher B GustafsonGaofeng Wang
Dec 5, 2014·Genome Medicine·Ken J KronMathieu Lupien
Apr 11, 2015·Clinical Epigenetics·Pier-Luc ClermontCheryl D Helgason
Dec 14, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Teresa Morales-RuizTeresa Roldán-Arjona
Jun 4, 2016·Molecular Medicine·Zhiqiang ZhaoLijun Di
Apr 24, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Xuegeng Wang, Ramji Kumar Bhandari
Feb 6, 2016·Cellular and Molecular Life Sciences : CMLS·Vladimir Camarena, Gaofeng Wang
Oct 25, 2013·Nature·Philipp Gut, Eric Verdin
Oct 25, 2013·Nature·Effie Apostolou, Konrad Hochedlinger
May 13, 2014·Cell and Tissue Research·Wibke Bechtel-Walz, Tobias B Huber
May 13, 2014·Cell and Tissue Research·Gerd P PfeiferSeung-Gi Jin
Jun 7, 2019·Journal of Zhejiang University. Science. B·Xue-Jun GuoXiang-Yuan Zhang
Jun 22, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Sara VasconcelosSofia Doria
Aug 20, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irfan A Qureshi, Mark F Mehler
Jul 3, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Nikhil JainYuval Ebenstein
Apr 30, 2014·The EMBO Journal·Luis M Tuesta, Yi Zhang
Dec 14, 2018·The EMBO Journal·Nathaniel E Wiest, Alan E Tomkinson
Mar 8, 2014·The Plant Journal : for Cell and Molecular Biology·Orlando de LangeThomas Lahaye
Apr 4, 2014·The Journal of Biological Chemistry·Akira SassaSamuel H Wilson
May 21, 2014·International Journal of Hematology·Mateusz BujkoJanusz Aleksander Siedlecki
Aug 20, 2014·British Journal of Pharmacology·David CheishviliMoshe Szyf
Aug 16, 2014·Immunological Reviews·Subhash K Tripathi, Riitta Lahesmaa
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ageliki TsagaratouAnjana Rao
Sep 3, 2014·Organic & Biomolecular Chemistry·Alexander C Drohat, Atanu Maiti
Sep 10, 2014·Reproduction, Fertility, and Development·Alan M O'Doherty, Paul A McGettigan
Feb 1, 2015·Reproduction, Fertility, and Development·Pablo Juan Ross, Sebastian Canovas
Jun 30, 2019·Cancers·Mohammed I Y Elmallah, Olivier Micheau
Jan 13, 2018·PloS One·Fei WangRuth Steward
Nov 30, 2018·Nucleic Acids Research·Marina AlexeevaSvein Bjelland
Oct 18, 2019·Antioxidants & Redox Signaling·Annekatrien BoelÉva Margittai
Sep 26, 2019·Essays in Biochemistry·Allegra Angeloni, Ozren Bogdanovic
Nov 23, 2019·Essays in Biochemistry·Oscar Ortega-Recalde, Timothy Alexander Hore
Oct 25, 2019·Cellular and Molecular Life Sciences : CMLS·Mafalda SantiagoC Joana Marques
May 23, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jing ZhangKenneth B Storey
Feb 15, 2020·Neuropathology and Applied Neurobiology·R D SalinasH Song
Feb 14, 2020·Molecular & Cellular Proteomics : MCP·Patrick HerrMikael Altun
Apr 11, 2020·PLoS Computational Biology·Luis Busto-MonerElizabeth L Read
Apr 2, 2020·The Journal of Clinical Endocrinology and Metabolism·Borbála SzabóHenriett Butz
Jan 11, 2020·AIMS Genetics·Asaad M Mahmood, Jim M Dunwell
May 6, 2020·Nucleic Acids Research·Shweta KarambelkarValakunja Nagaraja
Jun 20, 2019·PloS One·Fangfang SunEmmanuel Karouzakis
Jun 15, 2018·Oncotarget·María G GarcíaMario F Fraga
Nov 5, 2017·Oncotarget·Siqi FuQianjin Lu
Aug 22, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Qinmiao SunDahua Chen
Jun 17, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Daniel Castellano-CastilloMaría Isabel Queipo-Ortuño
Jul 13, 2019·Nature Communications·Ksenia SkvortsovaOzren Bogdanovic
Nov 23, 2017·Oncology Letters·Guofu LinJian Liang
Jan 25, 2019·Aging·Chiara CencioniFrancesco Spallotta
Nov 6, 2018·Aging·Na Yang, Payel Sen
Aug 19, 2020·Antioxidants & Redox Signaling·Stefano MasiSarah Costantino
Jun 10, 2014·Chemistry, an Asian Journal·Lining LuChengqi Yi
Jul 22, 2014·Cancer Science·Hideaki Nakajima, Hiroyoshi Kunimoto
Dec 30, 2014·The FEBS Journal·Sylvain FraineauMarjorie Brand
Feb 20, 2015·Reproduction, Fertility, and Development·Kun Zhang, George W Smith
Apr 22, 2015·British Journal of Haematology·Brunangelo FaliniMaria Paola Martelli
Jan 27, 2015·The International Journal of Neuropsychopharmacology·Yabin WeiCatharina Lavebratt
Sep 25, 2020·Chemical Society Reviews·Cécile MingardShana J Sturla
Sep 30, 2016·The Biochemical Journal·Xin Sun, Justin C St John
May 6, 2015·Nanotoxicology·Xiaoyan LuPhilip Demokritou
Jun 11, 2016·Acta Neuropathologica·Veronique V BelzilLeonard Petrucelli
Jul 22, 2016·PLoS Genetics·Samantha B SheltonBlerta Xhemalce
Nov 29, 2016·Clinical Epigenetics·T A L BreviniF Gandolfi
Jan 19, 2018·Metallomics : Integrated Biometal Science·Saki HanaokaYaichiro Kotake
Dec 26, 2017·Biology Methods and Protocols·Whitney BullardRobert Sabatini
May 17, 2018·Nature Communications·Mazhar Adli
Jul 17, 2018·Annals of the New York Academy of Sciences·Purva SinghMiguel Otero
Jan 18, 2019·Nature Reviews. Nephrology·Chunyuan GuoZheng Dong
Jul 17, 2019·The Journal of Clinical Investigation·Yan-Ping XuYue Xiong
May 13, 2020·Cancer Metastasis Reviews·Alejandra I FerrerPranela Rameshwar
May 30, 2020·Integrative and Comparative Biology·Beth McCawLesley T Lancaster
Apr 16, 2020·British Journal of Cancer·Sue HanChunzhang Yang
Jul 17, 2020·Protein & Cell·Ruimin XuShaorong Gao
Sep 9, 2020·Communications Biology·Yihong GuanBabal K Jha
Sep 26, 2020·Frontiers in Genetics·Kai WangMaureen A Sartor
Oct 28, 2014·Genes, Brain, and Behavior·Anthony R Isles
Nov 20, 2016·Cellular and Molecular Neurobiology·Yong Wang, Huaijin Guan
Aug 23, 2016·PloS One·Qiang XuQingkai Yang
Dec 8, 2015·Biochemistry. Biokhimii︠a︡·L A Zinovkina, R A Zinovkin
Jan 21, 2017·BioMed Research International·Mankgopo M KgatleHenry N Hairwadzi
Apr 30, 2017·Experimental & Molecular Medicine·Mirang Kim, Joseph Costello
Jun 7, 2017·Journal of Neuroendocrinology·N G Forger
May 18, 2017·Stem Cells International·Cristina D'AnielloGabriella Minchiotti
Aug 16, 2017·Oxidative Medicine and Cellular Longevity·Amy Guillaumet-AdkinsJuan Sandoval
Feb 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Javier Gallego-BartoloméSteven E Jacobsen
Jul 6, 2018·Cellular and Molecular Life Sciences : CMLS·Zijun WangQianjin Lu
May 11, 2018·Scientific Reports·Emmanuel KarouzakisCaroline Ospelt
Oct 19, 2018·Epigenetics & Chromatin·Sarah WyckRaffaella Santoro
Apr 27, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Ali M TabishSakthivel Sadayappan
Sep 26, 2019·Frontiers in Endocrinology·Isaac J Chamani, David L Keefe
Aug 14, 2019·Genome Biology and Evolution·Boris YagoundEmily J Remnant
Jul 18, 2019·International Journal of Molecular Sciences·Michal J Dabrowski, Bartosz Wojtas
Mar 28, 2019·Advances in Nutrition·Diego Hernández-SaavedraYuan-Xiang Pan
Jan 23, 2020·International Journal of Molecular Sciences·Taiga YamazakiKazuo Yamagata
Mar 24, 2020·Acta Histochemica Et Cytochemica·Kenta MasuiNoriyuki Shibata
Feb 22, 2020·Annual Review of Clinical Psychology·Kieran J O'Donnell, Michael J Meaney
Aug 3, 2020·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Samuele AmbrosiniFrancesco Paneni
Jul 28, 2020·Rheumatology International·Bohdana DoskaliukOlena Zimba
Jul 27, 2020·Epigenomics·Bernardo J KrauseJames Hamilton
Jan 31, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Varun Sasidharan NairKwon Ik Oh
Aug 27, 2017·Basic & Clinical Pharmacology & Toxicology·Ali Alavian-Ghavanini, Joëlle Rüegg
Aug 5, 2017·Frontiers in Molecular Neuroscience·Ernesto Miranda-MoralesOscar Arias-Carrión
Aug 26, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Luyuan LiJonathan C Trent
May 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Thomas DoddIvaylo Ivanov
Jun 6, 2018·Frontiers in Cell and Developmental Biology·Alexandre ChamprouxAyhan Kocer
Jun 28, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ilaria Palmisano, Simone Di Giovanni
Aug 9, 2018·Molecular Psychiatry·Masaki NishiokaTadafumi Kato
Feb 28, 2019·Frontiers in Immunology·Chan-Wang J Lio, Anjana Rao
Jun 27, 2019·Journal of Oncology·Narasimha Reddy ParineMohammad Alanazi
Oct 2, 2018·Current Pathobiology Reports·Thu Elizabeth Duong, James S Hagood
Oct 16, 2018·Frontiers in Oncology·Giuseppe BiamontiAlessandra Montecucco
Dec 21, 2018·International Journal of Molecular Sciences·Tian GaoFrancisco Verdeguer
Feb 9, 2019·International Journal of Genomics·Nathalie GrovaJonathan D Turner
Jan 4, 2019·Nature Cell Biology·Alfredo M Valencia, Cigall Kadoch
Jun 20, 2019·Frontiers in Immunology·Giselle M BoukhaledConnie M Krawczyk
Mar 16, 2019·Nutrients·Abeer M Mahmoud, Mohamed M Ali
Apr 20, 2019·Frontiers in Oncology·Yimei FengXi Zhang
Jun 20, 2019·International Journal of Molecular Sciences·Celeste CocoMonica Montagnani
Mar 7, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yukun LiuChristine G Lian
Jul 24, 2019·Nucleic Acids Research·Mengchi WangWei Wang
Oct 16, 2019·Frontiers in Immunology·Haijing WuQianjin Lu
Sep 14, 2019·American Journal of Physiology. Heart and Circulatory Physiology·YongFeng LiuHarold A Singer
Jan 30, 2020·Frontiers in Immunology·Fabiola Claudio-PiedrasHumberto Lanz-Mendoza
Jul 5, 2019·Nature Reviews. Molecular Cell Biology·Ewa M MichalakMark A Dawson
Sep 17, 2020·Nature Communications·Mi Ran KimChun Ju Chang
May 6, 2020·International Journal of Molecular Sciences·Tamás KovácsIstván M Ábrahám
Jun 17, 2020·Molecular Neurobiology·Steinunn Sara HelgudottirTorben Moos
May 31, 2015·Science China. Life Sciences·Renu A Kowluru, Manish Mishra
Dec 17, 2014·PLoS Genetics·Hiroaki OkaeTakahiro Arima
Apr 3, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia UdaliSimonetta Friso
Apr 7, 2017·Frontiers in Immunology·Priya D A IssureeDan R Littman
Jul 19, 2018·Frontiers in Physiology·Margreet C M Vissers, Andrew B Das
Feb 16, 2019·Nature Reviews. Urology·Sina JostesHubert Schorle
Jun 6, 2019·Epigenetics & Chromatin·Ting ZhangGang Li
Sep 22, 2019·International Journal of Molecular Sciences·Guixiang YuMingyao Yang
Aug 14, 2020·Cells·Sandra P NunesJesús M Paramio
Mar 21, 2020·Frontiers in Cardiovascular Medicine·Shafeeq A MohammedSarah Costantino
Jun 7, 2020·Analytical and Bioanalytical Chemistry·Natsumi Taka, Wataru Yoshida
Sep 19, 2020·Molecular & Cellular Oncology·Haider M HassanJoseph Torchia
Aug 1, 2015·American Journal of Physiology. Cell Physiology·Xiefan FangChristopher C Wendler
Aug 3, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jikui Song, Gerd P Pfeifer
Oct 1, 2015·Hepatic Oncology·Jeroen DekervelChris Verslype
Jun 19, 2019·Nature Chemistry·Zheng J LiuShankar Balasubramanian
Jul 16, 2020·Experimental & Molecular Medicine·Hanseul ParkJongpil Kim
Jan 1, 2019·Reproduction, Fertility, and Development·Rocío Melissa Rivera
Jan 7, 2015·Journal of Cellular Biochemistry·Mazhar AdliSamir S El-Dahr
May 29, 2018·CNS Neuroscience & Therapeutics·Jacob Peedicayil
Nov 9, 2014·G3 : Genes - Genomes - Genetics·Robert M ErdmannMary Gehring
Oct 13, 2016·Annual Review of Genetics·Leandro Quadrana, Vincent Colot
Apr 26, 2017·Nature Communications·Feng PanMingjiang Xu
Apr 20, 2019·Frontiers in Genetics·Wolfgang Wagner
Sep 26, 2019·Frontiers in Genetics·Olivia CyprisWolfgang Wagner
Oct 13, 2020·Frontiers in Neuroscience·Jenice Linde, Geraldine Zimmer-Bensch
Sep 11, 2020·Nature Reviews. Genetics·Ziwei DaiJason W Locasale
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Yuan GuFa-Xing Yu
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Boris YagoundBenjamin P Oldroyd
Dec 2, 2020·International Journal of Molecular Sciences·Jordy M M Kocken, Paula A da Costa Martins
Nov 24, 2020·Molecular Nutrition & Food Research·Shuang CaiShiyan Qiao
Jan 10, 2019·Cancer Research·Piotr T FilipczakSteven A Belinsky
Nov 7, 2019·Cancer Research·Ming YuWilliam M Grady
Sep 14, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Megan M NiedzwieckiMary V Gamble
Sep 26, 2020·Neuroscience and Biobehavioral Reviews·Stefania CiafrèMarco Fiore
Aug 12, 2019·Journal of Molecular Biology·Gerd P PfeiferJikui Song
May 16, 2020·Trends in Microbiology·Wesley Morovic, Charles R Budinoff
Aug 2, 2020·Seminars in Cancer Biology·Ammad Ahmad FarooqiMassimo Mallardo

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5-hydroxymethylcytosine
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Cytosine
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DNA Replication
Malignant Neoplasms
Oxidation-Reduction
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Thymine DNA Glycosylase
5-Methylcytosine Monohydrochloride

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