TET2 Mutation in Adult T-Cell Leukemia/Lymphoma.

Journal of Clinical and Experimental Hematopathology : JCEH
Kazuya ShimodaAkira Kitanaka

Abstract

Loss-of-function of ten-eleven translocation-2 (TET2) is a common event in myeloid malignancies, and plays pleiotropic roles, including augmenting stem cell self-renewal and skewing hematopoietic cells to the myeloid lineage. TET2 mutation has also been reported in lymphoid malignancies; 5.7~12% of diffuse large B-cell lymphomas and 18~83% of angioimmunoblastic T-cell lymphomas had TET2 mutations. We investigated TET2 mutations in 22 adult T-cell leukemia/lymphoma (ATLL) patients and identified a missense mutation in 3 cases (14%). TET2 mutation occurred in a number of ATLL patients and was likely involved in their leukemogenesis.

References

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Citations

Mar 24, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Yoko KubukiKazuya Shimoda
Oct 11, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Alberto Ponciano-GómezEfraín Garrido
Aug 14, 2019·Reviews in Medical Virology·Fateme TaheriEbrahim Faghihloo
Jun 11, 2020·Blood·Jarmila Stremenova SpegarovaSophie Hambleton
Jan 5, 2019·Epigenetics & Chromatin·Dimitrios CakourosStan Gronthos
Jan 11, 2021·Current Opinion in Genetics & Development·Shaneice R MitchellSiddhartha Jaiswal

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