PMID: 1190935Nov 1, 1975Paper

Tetany, malabsorption, and mastocytosis.

Archives of Internal Medicine
P I Dantzig

Abstract

Mastocytosis is characterized by increased proliferation of mast cells. Two patients had systemic mastocytosis involving the skin and gastrointestinal tract, complicated by malabsorption and tetany. Absorption studies in these patients suggested that the entire small bowel was involved and that the defect was mild in the absence of diarrhea. Small bowel biopsies disclosed infiltration of the lamina propria and submucosa by mast cells, and gastrointestinal tract x-ray films showed nodular densities, edema, and thickening of the bowel wall. Tetany was due in part to combined hypocalcemia, hypomagnesemia, and hypokalemia. Diarrhea and malabsorption were due to mast cell infiltration of the bowel rather than to histamine. patients with signs of systemic mastocytosis should have careful evaluations and be followed up to prevent development of malabsorption and tetany.

Citations

Aug 1, 1987·The British Journal of Radiology·T Y HuangC Y Li
Dec 6, 2008·World Journal of Gastroenterology : WJG·Jason K LeePeter Zetler
Mar 1, 1985·The American Journal of the Medical Sciences·M D Tharp
Jul 31, 2013·The Journal of Allergy and Clinical Immunology·Harry SokolOlivier Hermine
May 1, 1986·The American Journal of Medicine·L T YamC Y Li
Dec 1, 1982·Journal of the American Academy of Dermatology·R S DiBacco, V A DeLeo
Feb 18, 2010·Inflammatory Bowel Diseases·Harry SokolOlivier Hermine
Jan 1, 1984·Gastrointestinal Radiology·S F QuinnS Ross
Oct 22, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Richard KirschRobert H Riddell

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