Tether Me, Tether Me Not-Dynamic Organelle Contact Sites in Metabolic Rewiring

Developmental Cell
Maria Bohnert

Abstract

Membrane contact sites (CSs) are specialized cellular regions where distinct organelles are actively positioned very close to each other, at a distance of just a few nanometers. Structurally, CS formation depends on tether proteins that physically link organellar membranes to each other. Functionally, these structures act as hotspots for communication and material transfer. In recent years, we are starting to understand that the cellular CS landscape is not static but instead responds dynamically to diverse metabolic cues. This review describes the interplay between cellular metabolism and CS-based organelle communication and discusses molecular mechanisms of contact modulation in cellular adaptation to changing metabolic requirements.

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Citations

Feb 7, 2021·Trends in Cell Biology·Eva HerkerMaria Bohnert
Feb 21, 2021·The Journal of Biological Chemistry·Erika F DudásAnnalisa Pastore
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Bailey HewlettThierry Galli
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Louise H WongEmily R Eden
May 2, 2021·Current Opinion in Cell Biology·Rossella VendittiMaria Antonietta De Matteis
May 8, 2021·Frontiers in Cell and Developmental Biology·Kerry WoodsPhilipp Olias
Jun 2, 2021·ELife·Rebecca Martina Fausten, Maria Bohnert
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Fubito Nakatsu, Asami Kawasaki

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