Tethered capsule endomicroscopy for microscopic imaging of the esophagus, stomach, and duodenum without sedation in humans (with video).

Gastrointestinal Endoscopy
Michalina J GoraGuillermo J Tearney

Abstract

Patients with many different digestive diseases undergo repeated EGDs throughout their lives. Tethered capsule endomicroscopy (TCE) is a less-invasive method for obtaining high-resolution images of the GI mucosa for diagnosis and treatment planning of GI tract diseases. In this article, we present our results from a single-center study aimed at testing the safety and feasibility of TCE for imaging the esophagus, stomach, and duodenum. After being swallowed by a participant without sedation, the tethered capsule obtains cross-sectional, 10 μm-resolution, optical coherence tomography images as the device traverses the alimentary tract. After imaging, the device is withdrawn through the mouth, disinfected, and reused. Safety and feasibility of TCE were tested, focusing on imaging the esophagus of healthy volunteers and patients with Barrett's esophagus (BE) and the duodenum of healthy volunteers. Images were compared with endoscopy and histopathology findings when available. Thirty-eight patients were enrolled. No adverse effects were reported. The TCE device swallowing rate was 34 of 38 (89%). The appearance of a physiologic upper GI wall, including its microscopic pathology, was visualized with a tissue coverage of 85.4% ± 14.9%...Continue Reading

Citations

May 23, 2019·World Journal of Gastroenterology : WJG·David SteeleShajan Peter
Oct 2, 2019·Bioengineering & Translational Medicine·Si ChenLinbo Liu
Mar 21, 2019·Biomedical Optics Express·Chia-Pin LiangGuillermo Tearney
Jul 28, 2019·Current Gastroenterology Reports·Don C Codipilly, Prasad G Iyer
Nov 14, 2020·Annals of the New York Academy of Sciences·Hiroshi MashimoSatish K Singh
Feb 8, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jing DongGuillermo J Tearney
Jun 10, 2021·Gut·Alex J ThompsonUNKNOWN HUNGer Consortium
Aug 31, 2021·Biomedical Optics Express·Andreas WartakGuillermo J Tearney
Oct 17, 2021·Current Gastroenterology Reports·Matthew G Bell, Prasad G Iyer

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