Tetracycline and niacinamide control bullous pemphigoid but not pemphigus foliaceus when these conditions coexist

The Journal of Dermatology
Junko ShioharaTakashi Hashimoto

Abstract

Pemphigus and pemphigoid are different types of autoimmune bullous disease and can occur in the same patient. We report a female patient with this condition. At first, we diagnosed her with bullous pemphigoid, and we treated her with tetracycline, niacinamide and a topical steroid. Tense bullas disappeared shortly after that, but crusted erythemas mainly on her head and trunk persisted. We examined BP180 and desmoglein 1 enzyme-linked immunosorbent assays, and also histological features, which showed coexistence of bullous pemphigoid and pemphigus foliaceus concurrently. Therefore, we tried prednisolone, which could control both conditions. This case showed that tetracycline and niacinamide could control bullous pemphigoid, but could not control pemphigus foliaceus, and that prednisolone was effective for both conditions.

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Citations

Sep 20, 2011·Dermatologic Clinics·Benjamin S DanielDédée F Murrell
Mar 28, 2017·The Journal of Dermatology·Duerna TieEishin Morita
Dec 31, 2011·Journal of Veterinary Dentistry·Mary E BuelowCarol Lichtensteiger
Mar 29, 2021·Archives of Dermatological Research·Xin-Xing JinYa-Gang Zuo

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