Tetracycline hydrochloride: A potential clinical drug for radioprotection

Chemico-biological Interactions
Amit Alok, N K Chaudhury

Abstract

Radiation exposure in planned scenario necessarily requires radioprotector for protection against radiation injuries in tissues and organs. A large number of potential radioprotectors have been investigated but no approved radioprotector is available. Hence, in quest for radioprotector, repurposing of clinical drug is an approach which aims at finding the radioprotective potential of known drugs so that in case of untoward accident the knowledge could be translated to drug usage. In this study, we have investigated the radical scavenging properties of tetracycline pertaining to radioprotection. Our study suggests that tetracycline hydrochloride efficiently scavenges free radicals in ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid), DPPH (2,2-diphenyl-1-picrylhydrazyl) and FRAP (ferric reducing antioxidant power) assays. Hydroxyl radical scavenging assay has demonstrated its ability to scavenge gamma radiation induced free radicals by lowering the formation of malondialdehyde. Radiation causes damage to macromolecules and hence the protection offered by tetracycline hydrochloride to DNA and protein shows its radioprotective potential. Plasmid DNA relaxation study with pBR322 has shown that tetracycline hydrochloride...Continue Reading

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Citations

Aug 4, 2018·Current Molecular Pharmacology·Peyman AminiMasoud Najafi
Jul 25, 2019·Reviews in Medical Virology·Ailar SabbaghiAmir Ghaemi
Nov 5, 2020·Biomedicines·Elena ObradorAlegría Montoro

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