Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing

Materials Science & Engineering. C, Materials for Biological Applications
Alex Carvalho AlavarseJean-Jacques Bonvent

Abstract

Fibrous mats built from biopolymer have been extensively explored for tissue engineering due mainly to their mimic structure to the extracellular matrix. The incorporation of drug in such scaffolds represents a growing interest for control drug delivery system in order to promote the tissue repair. In the present work, we present an experimental investigation of morphological, thermal, mechanical, drug release, antibacterial and cytotoxicity properties of electrospun PVA/Chitosan and PVA/Chitosan/Tetracycline hydrochloride (TCH) mats for wound dressing. Fibrous mats with cross-linked three-dimensional nanofibers were formed from the polymer blends. A uniform incorporation of drug was achieved along the nanofibers with not significant change on the morphological and thermal properties of the mats. Furthermore, the TCH release profile with a burst delivery during the first 2h allows an effective antibacterial activity on the Gram-negative Escherichia coli as well as on the Gram-positive Staphylococci epidermidis and Staphylococcus aureus. In vitro indirect MTT assay also showed that the developed drug-loaded nanofibrous scaffolds have good cytocompatibility, which was confirmed by scratch assay, indicating that the investigated s...Continue Reading

Citations

Apr 21, 2018·Nanomaterials·Abdullah M Al-EniziAhmed A Elzatahry
Nov 6, 2018·Journal of Materials Science. Materials in Medicine·Robin AugustineSabu Thomas
Nov 20, 2018·Journal of Biomaterials Science. Polymer Edition·Hui YuPeifeng Liu
Sep 13, 2018·Current Stem Cell Research & Therapy·Shabnam MohebbiMasoud Mozafari
May 16, 2019·Journal of Medical Engineering & Technology·Farzaneh AavaniAkbar Karkhaneh
Jun 20, 2019·Expert Opinion on Drug Delivery·Barbara ViganiFranca Ferrari
Jan 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hillary MndlovuViness Pillay
Oct 14, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ayça Bal-ÖztürkEmine Alarçin
Oct 12, 2020·Journal of Pharmaceutical Sciences·Tracey Anastacia JecksonBapi Gorain
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Jinke YangGareth R Williams
Jul 14, 2019·International Journal of Pharmaceutics·Y Emre BulbulNursel Dilsiz
Jan 16, 2021·International Journal of Biological Macromolecules·Md Kaiser HaiderIck Soo Kim
Jun 11, 2020·Molecular Pharmaceutics·Shahriar SharifiMorteza Mahmoudi
Feb 13, 2021·International Journal of Molecular Sciences·Luis Castillo-HenríquezJosé Vega-Baudrit
Oct 26, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong LiuLinqi Shi
Apr 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Bingyan Li, Xuhong Yang
Feb 22, 2021·Drug Delivery and Translational Research·Pia KaiserMaike Windbergs
Mar 18, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cansu Ulker TuranYuksel Guvenilir
Aug 19, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Shahin HomaeigoharAldo R Boccaccini
May 1, 2021·Pharmaceutics·Andreea Teodora IacobLenuta Profire
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Misbah HameedPervaiz Akhtar Shah
Jun 1, 2021·Frontiers in Bioengineering and Biotechnology·Elda M Melchor-MartínezJuan Eduardo Sosa-Hernández
Jun 23, 2021·Journal of Biomaterials Science. Polymer Edition·Tainara de Paula de Lima Lima, Marcele Fonseca Passos
Aug 7, 2021·International Journal of Biological Macromolecules·Elbadawy A KamounEl-Refaie S Kenawy
Aug 8, 2021·Nanomaterials·Honghai LiYanchuan Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.