Tetracycline: levels achievable in gingival crevice fluid and in vitro effect on subgingival organisms. Part I. Concentrations in crevicular fluid after repeated doses

Journal of Periodontology
J M GordonS S Socransky

Abstract

The concentration of tetracycline in gingival crevice fluid and blood was determined using a sensitive bioassay after oral administration of repeated doses of tetracycline. Crevicular fluid was sampled by an intracrevicular technique from four gingival sites in each individual and blood was obtained by finger puncture. Four volunteers received doses of 250 mg of tetracycline-HCl either every 6 hours or every 12 hours and were sampled at hours 0 to 15, 21 to 36, 48 to 60 and 96 to 102. Volunteers given 250 mg every 6 hours had average crevicular fluid concentrations between 4 to 8 micrograms/ml and blood concentrations between 2 to 2.5 micrograms/ml after 48 hours. The levels in crevicular fluid and blood of volunteers who received 250 mg every 12 hours were 2 to 4 micrograms/ml and 0.3 to 1.4 micrograms/ml respectively after 48 hours. The results demonstrated that after repeated doses of tetracycline the crevicular fluid levels were typically 2 to 4 times the blood levels.

References

Jan 1, 1979·Journal of Periodontal Research·M A ListgartenR Parodi
Jul 1, 1979·Journal of Dental Research·M G NewmanC Anselmo
Aug 1, 1979·Journal of Clinical Periodontology·B L WilliamsJ Jorgensen
Oct 1, 1979·Journal of Clinical Periodontology·A C TannerS S Socransky
Sep 1, 1977·Journal of Periodontology·S S Socransky
Jan 1, 1974·Journal of Clinical Periodontology·J Kelstrup, E Theilade
May 1, 1969·The Journal of the American Dental Association·R J GencoS A Ellison
Mar 1, 1970·Journal of Dental Research·S A Ellison
Feb 1, 1980·Antimicrobial Agents and Chemotherapy·J M GordonS S Socransky
Apr 1, 1981·Journal of Clinical Periodontology·J M GordonS S Socransky

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Citations

Oct 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N S RamamurthyB R Rifkin
Feb 1, 1995·Journal of Dentistry·R A Seymour, P A Heasman
Feb 3, 1998·Journal of Pharmaceutical and Biomedical Analysis·D S Vienneau, C G Kindberg
May 9, 1998·International Journal of Antimicrobial Agents·G L Southard, K C Godowski
Jan 1, 1990·International Journal of Technology Assessment in Health Care·W J Loesche
Jan 6, 2001·Journal of Clinical Periodontology·I G NeedlemanN V Pandya
Aug 1, 1990·Journal of Clinical Periodontology·J Slots, T E Rams
Jun 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·E M Sarkiala-KesselS Asikainen
Mar 1, 1992·Journal of Clinical Periodontology·C HayesE Burdick
Feb 1, 1993·Journal of Clinical Periodontology·L A ChristerssonC S Puchalsky
Oct 1, 1994·Journal of Clinical Periodontology·P A RotzetterG Cimasoni
Oct 21, 1998·International Dental Journal·W J Killoy
Dec 1, 1987·Antimicrobial Agents and Chemotherapy·M S LantzD E Pearson
Jan 1, 1992·Antimicrobial Agents and Chemotherapy·K SuomalainenY T Konttinen
Oct 1, 1983·Journal of Periodontology·J M GoodsonS Dunham
Jan 1, 1987·Journal of Periodontology·D B Krill, H R Fry
Oct 1, 1989·Journal of Periodontology·W Al-JoburiE C Chan
Mar 23, 2011·Journal of Periodontology·Pin-Chuang LaiJohn D Walters
Sep 6, 1994·Annals of the New York Academy of Sciences·B R RifkinN S Ramamurthy
Aug 11, 2006·Journal of Clinical Periodontology·Argelia Almaguer-FloresLaurie-Ann Ximenez-Fyvie
Jul 1, 1983·Journal of Clinical Periodontology·C B WalkerS S Socransky
Oct 1, 1986·Journal of Clinical Periodontology·D PascaleW Arndt
Nov 1, 1986·Journal of Clinical Periodontology·W H van Palenstein Helderman
Jun 28, 2005·Dental Clinics of North America·Maria Emanuel Ryan
Jan 21, 2014·Pharmaceutical Development and Technology·Abeer Ahmed KassemElsayed Aboulmagd
May 3, 2008·The Journal of the American Dental Association·Stuart L Segelnick, Mea A Weinberg
Jan 14, 2005·The Journal of the American Dental Association·Tolga F TözümAtilla Bozkurt
Oct 1, 1992·The Journal of the American Dental Association·S G CiancioR Shafer
Nov 1, 1996·Annals of Periodontology·C H Drisko
Aug 1, 1993·Journal of Periodontology·J M Gordon, C B Walker
Feb 1, 1992·Journal of Periodontology·K OkudaD Aeppli
Feb 16, 2002·Journal of Periodontology·Lynn R FriesenWilliam J Killoy

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