Abstract
Sewage, a major source of bacterial contamination of the environment, can be an important health hazard. The presence of antibiotic-resistant bacteria in sewage can exacerbate this problem. The sources of antibiotic-resistant bacteria in sewage are, for this reason, worth identifying and addressing. The bacterial flora in the effluent of the Woodward Avenue Wastewater Treatment Plant (WAWTP) in Hamilton, Ontario, Canada, contains many antibiotic-resistant coliforms. Here we ask, are the antibiotic resistance genes in the coliforms in the effluent of WAWTP descended from a recent common ancestor strain? If so, the source could be identified and eliminated. If, on the other hand, the antibiotic resistance genes in the bacterial flora of the WAWTP have more than one origin, identification and elimination of the source(s) could be difficult. There was considerable diversity of antibiotic resistance patterns and antibiotic resistance genes among the effluent and influent coliform isolates of the WAWTP, suggesting multiple genetic ancestry. The patterns of horizontal transmissibility and sequence differences in the genes tetA and tetE among these coliform isolates also suggest that they have no one predominant ancestral strain. Using...Continue Reading
References
Jun 1, 1979·Journal of Bacteriology·R A Jorgensen, W S Reznikoff
Oct 15, 1991·Annals of Internal Medicine·J W ChowV L Yu
Jan 1, 1981·Molecular & General Genetics : MGG·A Labigne-RousselP Courvalin
May 1, 1983·Gene·K W Peden
Mar 1, 1994·Applied and Environmental Microbiology·S R Andersen, R A Sandaa
Oct 1, 1995·Molecular and Cellular Probes·A DePaola, M C Roberts
Jun 1, 1996·Antimicrobial Agents and Chemotherapy·L M HansenD C Hirsh
Oct 1, 1996·FEMS Microbiology Reviews·M C Roberts
Aug 31, 2000·Applied and Environmental Microbiology·G RhodesR W Pickup
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·I Chopra, M Roberts
Nov 28, 2001·Applied and Environmental Microbiology·A S SchmidtJ L Larsen
Mar 28, 2002·Applied and Environmental Microbiology·R I AminovR I Mackie
Aug 2, 2002·Plasmid·Trine M L'Abée-Lund, Henning Sørum
Jan 28, 2004·Journal of Microbiological Methods·Keith E SimmonMalcolm S Shields
Sep 1, 1951·Journal of Bacteriology·G BERTANI
Apr 28, 2005·Molecular Microbiology·Kevin L GriffithRichard E Wolf
Aug 27, 2005·Canadian Journal of Microbiology·Thomas A Edge, Stephen Hill
Jan 21, 2006·Science·Vanessa M D'CostaGerard D Wright
Oct 6, 2006·Applied and Environmental Microbiology·Mohamed NawazRoger Steele
Jul 8, 2009·Applied and Environmental Microbiology·Chuanwu XiJerome Nriagu
Aug 19, 2009·The Journal of Antimicrobial Chemotherapy·David M Livermore