PMID: 8968030Dec 1, 1996Paper

Tetracycline/flurbiprofen combination therapy modulates bone remodeling in ovariectomized rats: preliminary observations

Bone
M AoyagiLorne M Golub

Abstract

The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of postmenopausal osteoporosis. In this study, two bone-modulating compounds, an NSAID (flurbiprofen: FBP) and a chemically modified nonantimicrobial tetracycline (CMT), were tested either individually or in combination in this model. Ninety days after OVX, 6-month-old female rats were distributed into the following groups: sham-operated controls, untreated OVX, CMT-treated OVX (5 mg P.O./day), FBP-treated OVX (0.3 mg P.O./day), and combination (CMT plus FBP)-treated OVX (COMBO) groups. Untreated 3-month-old rats were used as pretreatment group. After 21 days of therapy, the dissected distal femurs were processed for light and fluorescence microscopic and backscattered electron microscopic examinations. Net trabecular bone values showed that all the treatment groups lost trabecular bone over the 111 day protocol compared to pretreatment group. In the untreated OVX rats, trabecular bone volume/unit area was reduced by 56% compared to that in the sham-operated controls, this bone loss associated with increased numbers of osteoclasts (p < 0.05). Cortical bone volume was, however, not significantly reduced in OVX rats. Both FBP-alone an...Continue Reading

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Citations

Nov 16, 2002·International Journal of Pharmaceutics·Ping Li, Luwei Zhao
Nov 25, 2000·Journal of Pharmacological and Toxicological Methods·A S DumontR J Hurlbert
Jun 24, 2000·Bone·J T BettanyP S Grabowski
Apr 17, 2001·American Journal of Therapeutics·K M VerburgP C Isakson
Feb 18, 2014·Journal of Ethnopharmacology·Bingjiang XiaPeijian Tong
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Louis C GerstenfeldThomas A Einhorn

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