Tetracyclines metal complexation: Significance and fate of mutual existence in the environment

Environmental Pollution
Rama PulicharlaRao Y Surampalli

Abstract

Concern over tetracyclines (TCs) complexation with metals in the environment is growing as a new class of emerging contaminants. TCs exist as a different net charged species depending on their dissociation constants, pH and the surrounding environment. One of the key concerns about TCs is its strong tendency to interact with various metal ions and form metal complexes. Moreover, co-existence of TCs and metals in the environment and their interactions has shown increased antibiotic resistance. Despite extensive research on TCs complexation, investigations on their antibiotic efficiency and pharmacological profile in bacteria have been limited. In addition, the current knowledge on TCs metal complexation, their fate and risk assessment in the environment are inadequate to obtain a clear understanding of their consequences on living systems. This indicates that vital and comprehensive studies on TCs-metal complexation, especially towards growing antibiotic resistance trends are required. This review summarizes the role of TCs metal complexation on the development of antibiotic resistance. Furthermore, impact of metal complexation on degradation, toxicity and the fate of TCs in the environment are discussed and future recommendatio...Continue Reading

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Citations

Oct 21, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Dariusz OnichimowskiMirosław Czuczwar
Dec 10, 2019·Journal of Biomolecular Structure & Dynamics·Maria Dayanne de A DantasJosué Carinhanha C Santos
May 30, 2020·International Journal of Molecular Sciences·Tao ZhaoJunping Wang
Sep 20, 2020·Environmental Science and Pollution Research International·Junfeng SuLei Xue
Mar 27, 2018·Environmental Science and Pollution Research International·Linke GeZiwei Yao
Dec 8, 2019·Environmental Technology·Ramiro Pereira BisogninRenato Zanella
Jul 10, 2019·Veterinary Medicine and Science·Julieta M DecundoAlejandro L Soraci
Oct 10, 2020·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Dariusz OnichimowskiMirosław Czuczwar
Nov 20, 2020·The Science of the Total Environment·Longyao XuGuibin Jiang
May 24, 2020·Chemosphere·Pavla KovalakovaVirender K Sharma
Jul 20, 2021·The Science of the Total Environment·Meng WangTaowu Ma
Jul 31, 2021·Journal of Hazardous Materials·Ying CaiJinhong Fan

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