PMID: 7011047Mar 1, 1981Paper

Tetraethylammonium modifies gap junctions between pancreatic beta-cells

The American Journal of Physiology
M S Sheppard, P Meda

Abstract

Gap junctions between pancreatic beta-cells were quantitatively assessed in freeze-fracture replicas of isolated rat islets of Langerhans incubated for 90 min with or without the potassium conductance blocker tetraethylammonium (TEA). The results show that TEA increases the median number of particles per beta-cell gap junction but not the frequency of gap junctions at both nonstimulating and threshold-stimulating concentrations of glucose. TEA increased the relative gap junctional area at both concentrations of glucose. TEA had no effect on insulin release at a basal concentration of glucose but potentiated that release at the threshold glucose level. Thus TEA modifies beta-cell gap junctions independently of its effect on insulin release. However, the junctional changes observed were greater when insulin release was also elevated.

References

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Sep 1, 1967·Canadian Journal of Physiology and Pharmacology·G Beaulieu, G B Frank
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Jan 1, 1980·International Review of Cytology·C Peracchia
Mar 3, 1980·Brain Research·P A Schwartzkroin, D A Prince

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Citations

Nov 6, 2007·Biological & Pharmaceutical Bulletin·Matheus Lavorenti Rocha, Lusiane Maria Bendhack
Jan 29, 2005·British Journal of Pharmacology·Christian Aalkjaer, Holger Nilsson
Jul 18, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Quan ZhangPatrik Rorsman
Nov 2, 2011·Biological & Pharmaceutical Bulletin·Matheus Lavorenti RochaLusiane Maria Bendhack

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