Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway.

Signal Transduction and Targeted Therapy
Junyao ZhuYunfeng Lin

Abstract

While the skin is considered the first line of defense in the human body, there are some vulnerabilities that render it susceptible to certain threats, which is an issue that is recognized by both patients and doctors. Cutaneous wound healing is a series of complex processes that involve many types of cells, such as fibroblasts and keratinocytes. This study showed that tetrahedral framework nucleic acids (tFNAs), a type of self-assembled nucleic-acid material, have the ability to promote keratinocyte(HaCaT cell line) and fibroblast(HSF cell line) proliferation and migration in vitro. In addition, tFNAs increased the secretion of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in HSF cells and reduced the production of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) in HaCaT cells by activating the AKT-signaling pathway. During in vivo experiments, tFNA treatments accelerated the healing process in skin wounds and decreased the development of scars, compared with the control treatment that did not use tFNAs. This is the first study to demonstrate that nanophase materials with the biological features of nucleic acids accelerate the healing of cutaneous wounds and reduce scarr...Continue Reading

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Citations

Mar 4, 2021·ACS Applied Materials & Interfaces·Qirong LiYunfeng Lin
Sep 26, 2020·ACS Applied Materials & Interfaces·Tao ZhangYunfeng Lin
Oct 9, 2021·Signal Transduction and Targeted Therapy·Wenjuan MaYunfeng Lin
Oct 20, 2021·ACS Applied Materials & Interfaces·Shaojingya GaoYunfeng Lin

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Methods Mentioned

BETA
electrophoresis
enzyme-linked immunosorbent assay
ELISA
flow-cytometry
PCR
fluorescence microscopy

Software Mentioned

Pro Plus
Image
FlowJo
GraphPad Prism

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