Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala

Brain Research Bulletin
S J WangP W Gean

Abstract

The effect of the centrally active anticholinesterase inhibitor tetrahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by alpha-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.

References

Oct 1, 1992·Neuroscience·M S Washburn, H C Moises
Nov 13, 1986·The New England Journal of Medicine·W K SummersA Kling
Oct 6, 1987·European Journal of Pharmacology·M A Rogawski
Aug 31, 1987·Neuroscience Letters·D R Stevens, C W Cotman
Jul 30, 1982·Science·R T BartusA S Lippa

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